pmid stringlengths 4 8 | title stringlengths 1 1.27k | text stringlengths 1 14.3k |
|---|---|---|
8044771 | ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements. | Rearrangements of the ALL-1 gene by reciprocal translocations involving chromosome band 11q23 are frequently associated with human acute leukemia. We have previously reported the detection of ALL-1 gene rearrangements in adult patients with acute myeloid leukemia lacking cytogenetic evidence of 11q23 translocations. Th... |
8044770 | Antiproliferative effects of enediynes on AIDS-derived Kaposi's sarcoma cells. | We have investigated the antiproliferative and cytotoxic effects of selected enediynes against three Kaposi's sarcoma (KS) cell lines. The enediynes tested were found to be very potent in inhibiting the growth of KS cells. Treatment with concentrations of 10(-10) M or less were capable of producing 50% inhibition of gr... |
8044769 | Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. | Transcriptional regulation of the promoter/enhancer region of the Egr-1 gene is activated by ionizing radiation. We linked DNA sequences from the promotor region of Egr-1 to a complementary DNA sequence which encodes human tumor necrosis factor (TNF) alpha, a radiosensitizing cytokine. The Egr-TNF construct was transfe... |
8044768 | Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. | A mouse fibrosarcoma cell line (FSa-II), which exhibits low endogenous levels of manganese superoxide dismutase, was transfected with a human manganese superoxide dismutase complementary DNA. Fifty clones were screened for manganese superoxide dismutase activity by the superoxide dismutase activity gel assay. Activity ... |
8044766 | Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma. | The role of some RNases as antitumoral agents has been recently emphasized. We have previously demonstrated a striking inhibitory effect of bovine seminal RNase on the in vitro growth of tumor cells of metastatic origin. This has prompted us to test the effects of this protein in vivo on the induction of metastatic foc... |
8044767 | Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes. | Studies by comparative genomic hybridization have indicated that a major new locus for DNA amplification in breast cancer is 20q13 and suggested that this genetic event is associated with aggressive clinical behavior. We used interphase fluorescence in situ hybridization with anonymous cosmid probes and gene-specific P... |
8044757 | The seroprevalence of maedi-visna in Ontario sheep flocks and its relationship to flock demographics and management practices. | The objectives of this study were to describe the serological prevalence of maedi-visna in a sample of Ontario sheep flocks, and to identify management and demographic variables that were associated with seroprevalence for maedi-visna. A sample of 103 sheep flocks in Ontario was randomly selected from those flocks part... |
8044756 | Hyperplasia of the thyroid gland and concurrent musculoskeletal deformities in western Canadian foals: reexamination of a previously described syndrome. | A syndrome of neonatal foals characterized by hyperplasia of the thyroid gland and concurrent musculoskeletal deformities (TH-MSD) has been described in western Canada and may be increasing in incidence. In an attempt to improve recognition and understanding of this syndrome, 2946 records of equine abortuses, stillborn... |
8044754 | Postoperative evaluation of the surgical treatment of accessory teat and gland cistern complexes in dairy cows. | The purpose of this study was the long-term evaluation of a method of surgically repairing the abnormal condition of accessory teat and gland cistern complexes in dairy cattle. A prospective evaluation of three cows that had undergone the procedure was done. These cows were evaluated from four months to one year, posto... |
8044748 | Shoplifting and mental illness. | A survey of 1,649 shoplifting convictions at a Montreal area municipal court found that a relatively low percentage (3.2%) of the cases involved mentally ill patients and that there is a comparatively closer link between shoplifting and affective disorders, alcoholism and drug addiction. The survey also showed that sho... |
8044747 | Clinical and demographic characteristics of voluntary and involuntary psychiatric inpatients. | Voluntary and involuntary psychiatric inpatients were compared on demographic, social and clinical characteristics. Chi-squared tests of independence revealed significant differences in age and financial support based on status at admission. No significant differences were found with respect to diagnostic category. It ... |
8044746 | Severe hypotension associated with combined lithium and chlorpromazine therapy: a case report and a review. | The case of a patient who developed a severe hypotensive reaction with a persistent hemianaesthesia following the addition of lithium carbonate to her treatment regimen is described. The patient had been receiving chlorpromazine therapy for the management of hypomania and the addition of lithium carbonate to the chlorp... |
8044745 | Prevalence of pathological gambling and related problems among college students in the Quebec metropolitan area. | The prevalence of pathological gambling and problems associated with it were measured among 1,471 students of three colleges in the Quebec city metropolitan area. Almost 90% of the students had gambled and 21.7% of the students engage in this behaviour once a week or more. The prevalence of pathological gamblers was fo... |
8044744 | Depression, mastery and number of group sessions attended predict outcome of patients with panic and agoraphobia in a behavioural/medication program. | From a list of 214 patients suffering from panic and agoraphobia and who had been treated with cognitive behaviour therapy, 30 patients who had very good outcomes and 32 who had poor outcomes were selected. The groups were selected by the nurse therapist and psychiatrist on the basis of personal knowledge of the patien... |
8044743 | Depression and hopelessness in children with disruptive behaviour disorders. | The purpose of this study was to investigate the prevalence of depression in a day treatment compared to a control population of children and to determine whether or not day treatment is effective in normalizing depression and hopelessness. Twenty-five control children, matched by age and sex, were compared on self-rep... |
8044742 | Personality diagnosis and childhood care associated with adult marital quality. | This paper reports on a continuation of previous research into the connection between childhood experience of relationships and adult relationships such as marriage. A group of 41 married, mixed psychiatric patients showed the strongest correlations between adult marital quality as measured by the Marital Adjustment Te... |
8044741 | Psychological risk factors and self-mutilation in male patients with BPD. | The purpose of this study was to determine whether or not self-mutilation in patients with personality disorders is related to other psychological risk factors, dissociation or diagnosis. The sample included 61 subjects with borderline personality disorder and 60 subjects with nonborderline personality disorder; 32 sub... |
8044740 | Psychological risk factors for dissociation and self-mutilation in female patients with borderline personality disorder. | The purposes of this study were to determine whether or not dissociation in female patients suffering from personality disorder is related to sexual and physical abuse or to abuse parameters and whether or not self-mutilation in the personality disorders is related to psychological risk factors or to dissociation. The ... |
8044739 | The prevalence of dementia in the elderly: a review. | We reviewed the findings of the Canadian Study of Health and Aging in the context of studies published between January 1986 and June 1993 that documented dementia and Alzheimer's disease prevalence. Studies were identified using a MEDLINE literature search. Additional references were selected from the bibliography of i... |
8044732 | Clozapine and seizures: a review. | Clozapine, a novel antipsychotic agent, is an alternative to standard neuroleptic therapy for psychotic disorders. Some advantages of clozapine over neuroleptics are that it may be a more effective antipsychotic in treatment resistant patients and has a lower incidence of extrapyramidal side effects. However, seizures ... |
8044731 | [Violent and intimidating behavior of psychiatric patients at admission]. | The dangerousness of the mentally ill patient is still unknown. This study assesses the actual prevalence of violent and intimidating behaviours in psychiatric patients at the time of their admission, or in the days leading up to their admission to a Quebec hospital. These behaviours have been measured on a six-point s... |
8044730 | Delinquent firesetters: a comparative study of delinquency and firesetting histories. | Twenty-five male delinquents (aged nine to 16) who had legal charges for setting fires filed against them were compared to a group of age and sex matched delinquents who had legal charges filed against them that were not related to firesetting. Groups were compared on demographic variables and on their delinquency and ... |
8044729 | Fluphenazine treatment of DSM-III-R male schizophrenic patients among the Xhosa. | A comparison of fluphenazine decanoate depot injection used alone and fluphenazine decanoate with fluphenazine HCl i.m. was undertaken in South African Xhosa patients with schizophrenia diagnosed according to DSM-III-R. The combined treatment significantly shortened the length of hospital stay to a mean of 30.5 days fr... |
8044728 | Do child and/or parent bereavement programs work? | Bereavement programs for children and parents are becoming popular since there are more and more neonatal intensive care programs, pediatric oncology programs and pediatric intensive care programs offering these services. This paper addresses the following question: Do bereavement programs work? An overview of the lite... |
8044727 | [Presentation of a case: encephalopathy of boxers]. | A 68-year-old man presents slight memory problems and behavioural change over a period of a year. A history of boxing is identified. Neuropsychological examination confirms slight frontal cognitive damage and damage at the level of the motor signs of the upper left hemicorpus. This symptomatology should, in differentia... |
8044726 | Fitness and competency issues in Canadian criminal courts: elucidating the standards for mental health professionals. | The issue of competency arises at various stages of criminal proceedings in an effort to protect those individuals who are unable to participate in the legal process. The competency question is a legal issue ultimately decided by a judge. However, mental health professionals are often called upon to provide insight int... |
8044725 | Regression in the service of the superego: the do's and don'ts of stepwise multiple regression. | Stepwise multiple regression is a very powerful but often misused technique. It can be used to find a set of independent variables which can predict some outcome. However, there are problems when the results of a stepwise solution are used to try to explain or understand the dependent variable. This paper discusses the... |
8044724 | Cardiac screening of children with Down's syndrome. | To establish the role of clinical and laboratory investigation of the cardiovascular system in children with Down's syndrome. Prospective evaluation; examiners blinded to results of laboratory studies. Tertiary pediatric referral centre. Fifty consecutive children with Down's syndrome presenting to a regional genetic c... |
8044722 | Diagnosis and management of heart failure. Canadian Cardiovascular Society. | Many of the recommendations presented in this consensus report are summarized in Figure 2. All patients with known or suspected heart failure should undergo a detailed history and physical examination. Other causes for the symptoms and/or clinical signs indicative of heart failure should be excluded. Routine biochemica... |
8044721 | Discrepancies between clinic and ambulatory blood pressure responses to cilazapril therapy. | To evaluate the antihypertensive effects of cilazapril, a new angiotensin-converting enzyme inhibitor, on clinic and ambulatory blood pressure (ABP) after first and last dose administrations. Four weeks randomized, double-blind, controlled trial of three regimens. Six hypertensive research clinics in Canada. After a tw... |
8044719 | Does dental health education affect inequalities in dental health? | The aim of the study was to evaluate the Lothian 1991 dental health campaigns on 5-year-old schoolchildren's oral hygiene and gingival health in relation to deprivation. A stratified random sample of 486 children was selected from 92 primary schools in the city of Edinburgh. Clinical examinations took place immediately... |
8044718 | Prevalence of long-term use of liquid oral medicines by children in the northern region, England. | The aim of the study was to assess the prevalence of frequent administration of liquid oral medicines, long-term, in children aged 1-16 years in a number of districts within the Northern Region in 1989-91. This was achieved through two surveys, one conducted amongst consultant paediatricians in five districts, and the ... |
8044717 | The shortened dental arch: supplementary analyses from the 1988 adult dental health survey. | Information on 2297 dentate adults, aged 15-75+ years, who participated in the 1988 national survey of adult dental health in the United Kingdom, was reviewed in order to determine what proportion in each age group fulfilled the criteria for a 'shortened dental arch'. The proportion of people with four good quadrants w... |
8044716 | The prevalence of tooth wear in 14-year-old school children in Liverpool. | The prevalence of tooth wear was assessed in a random sample of 14 year old school children in Liverpool. A total of 1035 children were examined in 10 schools of whom 526 (50.8 per cent) were male and 509 (49.2 per cent) were female. Three hundred and seven children (30 per cent) had exposed dentine, mainly incisally, ... |
8044715 | A critical review of methods for the economic evaluation of fissure sealants. | Economic evaluation provides a method of systematically comparing the costs and outcomes of alternative health care programmes. It is being used increasingly to provide planning information. However, a review of the literature on economic evaluation of fissure sealants revealed a number of problems within studies. Thes... |
8044714 | Prevalence of fluorosis and other enamel defects related to caries among adults in communities with optimal and low water fluoride concentrations. | The aim of this Swedish study, performed in 1982, was to determine the prevalence of fluorotic and nonfluorotic enamel defects among adults in areas with optimal and low fluoride concentrations in water. The fluorosis prevalence was also related to caries prevalence in these areas. The study was based on clinical exami... |
8044713 | Ethanol and pH levels of proprietary mouthrinses. | This study measured the pH and alcohol (ethanol) content of a number of proprietary mouthrinses available for purchase by the general public, as well as assessing the influence of the alcohol content on police exhaled air analysis (breathalysing) procedures. The majority of the mouthrinses were acidic, some with a pH a... |
8044712 | Factors of deprivation associated with dental caries in young children. | Quantitative and qualitative data were collected on the communities in the Tameside and Glossop Health Authority district served by the five primary schools with the highest prevalences of dental caries among their 5-year-old children and contrasted with similar information from communities served by five schools whose... |
8044708 | A survey of the training, practice and dental health knowledge of traditional dentists practising in Phnom Penh, Cambodia. | Interviews with 50 traditional dentists practising in Phnom Penh, Cambodia showed that the majority had been trained as an apprentice of either their father or a relative. The most frequently undertaken treatment procedures were tooth coloured fillings, and cast, preformed metal or acrylic crowns and bridges. Knowledge... |
8044707 | Lay perspectives on oral hygiene performance: their use in hypothesis development. | This paper examines issues related to oral hygiene performance. Results from interviews with 113 adults who had received oral hygiene instruction in eight general dental practices are presented with an emphasis on three issues--the respondents' tooth cleaning pattern (the location within other routines of tooth cleanin... |
8044706 | Participation, willingness and abilities of school-teachers in oral health education in Tanzania. | In Tanzania, teachers in primary schools conduct oral health education as part of the school syllabus, most of them without any training for the task. The participation, willingness and abilities of teachers involved in this duty were studied by means of questionnaire, interviews, oral hygiene examinations and practica... |
8044705 | Deficiency of the 50 kDa dystrophin associated glycoprotein (adhalin) in severe autosomal recessive muscular dystrophies in children native from European countries. | A large oligomeric complex of sarcolemmal glycoproteins is associated with dystrophin, the protein absent in Duchenne muscular dystrophy (DMD). The dystrophin-glycoprotein complex spans the sarcolemma, providing a link between the subsarcolemmal cytoskeleton and the extracellular matrix. It was recently shown that one ... |
8044704 | Identification of barley oxalate oxidase as a germin-like protein. | A barley oxalate oxidase was purified to homogeneity and the N-terminal sequences of the protein and of two peptides generated by CNBr cleavage of this protein were determined. Searches for similarities in data bank revealed that the sequences are highly homologous to the amino-acid sequence of a wheat protein, germin,... |
8044703 | Antifungal properties of lectin and new chitinases from potato tubers. | We have purified from potato tubers, the lectin STA devoid of chitinase activity and two chitinases devoid of lectin activity. Both enzymes are 16 kDa glycoproteins, and probably belong to a new family of plant chitinases. The respective antifungal properties of lectin and chitinases were studied by following their eff... |
8044702 | Adaptive phosphate uptake behaviour of the cyanobacterium Anacystis nidulans: analysis by a proportional flow-force relation. | The phosphate uptake system of the cyanobacterium Anacystis nidulans has the capacity to store information about former fluctuations in the environmental phosphate concentration. Using nonequilibrium thermodynamics to characterize this phenomenon we show that information storage leads to the development of an extended ... |
8044700 | Transforming growth factor beta 1-mediated growth inhibition in chick embryo fibroblasts: reversion by virally-expressed nuclear oncogenes. | Transforming growth factor beta 1 (TGF-beta 1) inhibits growth of primary cultures of chick embryo fibroblasts by affecting G1 and strongly increasing the generation time. This inhibition is reversed by the nuclear oncogenes v-jun, v-fos, v-myc, but not v-erbA and v-ets. It is also reversed by v-myb from either avian m... |
8044701 | Resistance of NOD mice to salmonellosis. | The NOD mouse strain has become one of the most popular animal models for exploring insulin dependent type 1 diabetes. Genetic studies have underlined the polygenic nature of the murine disease. Two such genes were mapped on chromosome 1. One, associated with diabetes onset, is strongly linked with the Lsh, Ity, bcg ge... |
8044699 | Characterization of a molecular clone of a highly infectious avian leukosis virus. | A highly infectious avian leukosis virus (ALV) has been molecularly cloned in a Lambda phage and sequenced. In order to manipulate the genome of this ALV and characterize the genetic determinants responsible for the high infectivity phenotype, a recombinant plasmid DNA with the two LTR provirus was constructed. Upon tr... |
8044698 | [Cloning and sequence of thyrotropin beta subunit of a teleost fish: the eel (Anguilla anguilla L.)]. | We obtained the sequence of eel thyrotropin beta-subunit cDNA. About 1,100 bp long, it encodes a 147-amino acid protein including a 20-residue signal peptide. We analyse homologies between angTSH beta and the other known beta-subunits taking in account the ability of mammal gonadotropins (GTH) to stimulate teleost thyr... |
8044697 | Spatial distribution of viable cells immobilized in agar membranes. | The biocatalytic structures obtained by immobilizing microorganisms in planar gel slabs have been studied and modeled to better understand the dynamics of systems controlled by diffusion-reaction-growth couplings. The theoretical results give two kinds of information: the time evolution of the extra-membrane system due... |
8044696 | [Fertilization and development of axolotl oocytes with already grey crescent experimentally formed during their maturation]. | Pigmented axolotl coelomic oocytes were induced to form a gray crescent by simultaneous action of a gravity vector and of a heat-shock (36 +/- 0.5 degree C during 10-15 min), according to a previously described method. Those oocytes were subsequently reintroduced into the coelomic cavity of an albino recipient female, ... |
8044695 | [Proposition of a new classification of the phylum of the protozoa Ciliophora Doflein, 1901]. | It is proposed to use all the presently available molecular, ultrastructural, biological and ecological data on ciliates for the new classification of this group of protists. On the basis of the cortical organization and the mode of cilia anchoring as well as the degree of conservation of the cortical pattern during th... |
8044694 | The muscle specific promoter of chick beta tropomyosin gene requires helix-loop-helix myogenic regulatory factors and ubiquitous transcription factors. | The chick beta tropomyosin (TM) gene has two alternative transcription initiation start sites which are used in muscle or non muscle tissue. A recombinant plasmid containing 805 nucleotides (nt) of the sequence upstream to the muscle CAP site driving the bacterial chloramphenicol acetyltransferase gene is sufficient fo... |
8044693 | Dream report length is more dependent on arousal level than prior REM duration. | Twenty two young adult subjects (Ss) were monitored for 2 consecutive nights in the sleep laboratory. Each S was awakened three times per night: at sleep onset and during the second (REMP2) and fourth (REMP4) REM periods. Length of time in each REMP prior to awakening was either 5 or 10 min, counterbalanced on successi... |
8044692 | Cocaine-induced deficits in ACTH and corticosterone responses in female rat progeny. | The objective of this study was to determine whether prenatal exposure to cocaine could produce functional changes in central serotonergic systems mediating neuroendocrine responses in female progeny. Pregnant rats were administered either saline or (-) cocaine (15 mg/kg, SC, b.i.d.) from gestational day 13-20. Progeny... |
8044691 | Macronutrient type independently of energy intake modulates hypothalamic neuropeptide Y in Long-Evans rats. | Neuropeptide Y (NPY) induces a robust feeding response when it is injected in the hypothalamus. It stimulates both carbohydrate and fat intakes. Diets rich in either macronutrient are known to induce obesity and to modify feeding behavior. The aim of the present study was to determine the effects of long-term ingestion... |
8044690 | Changes in sciatic nerve and spinal cord function induced by a CNS viral infection. | Electrophysiologic response characteristics of mouse sciatic nerve and spinal cord were investigated following CNS infection with the temperature-sensitive (ts) vesicular stomatitis virus (VSV) mutant G31 KS5. Measurements were obtained before clinical symptoms of the virus-induced CNS disease appeared. Sciatic nerve p... |
8044689 | Spatial working memory score of humans in a large radial maze, similar to published score of rats, implies capacity close to the magical number 7 +/- 22. | To compare the working memory (WM) capacity of humans to rats, we tested humans with a 17-arm radial maze and, in a follow up experiment, with a 13-arm radial maze. Both mazes were 15.2 meters in diameter, painted on a grassy field. In one version of the 13-arm experiment, we required a concurrent nonsense vocalization... |
8044688 | Leukocyte involvement in cerebral infarct generation after ischemia and reperfusion. | White blood cell involvement in the generation of cerebral infarcts was evaluated following ischemia and reperfusion injury in the rat. Control and leukopenic rats (induced by vinblastine, WBC counts < 1500/mm3) were compared in a global forebrain ischemic model after 1 h of ischemia and 1 h 15 min of reperfusion. Cere... |
8044687 | Time course of purine protection against kainate-induced increase in hippocampal [3H]-PK11195 binding. | Binding of a peripheral benzodiazepine receptor ligand was used to quantify the reactive gliosis resulting from neuronal damage induced by systemic injections of kainic acid 7 days previously. The enhancement of binding in rat hippocampus could be prevented by injections of the purine analogue (R)-N6-phenylisopropylade... |
8044686 | Microanatomical changes in the frontal cortex of aged rats: effect of L-deprenyl treatment. | The present study was designed to assess whether treatment with L-deprenyl has any effect on the age-related microanatomical changes in the rat frontal cortex. Male Sprague-Dawley rats of 19 months of age were treated until the 24th month with an oral daily dose of 1.25 mg/kg or of 5 mg/kg of L-deprenyl. Eleven-month-o... |
8044685 | Hormone and somatic changes in rats pair-fed to growth retarded dorsomedial hypothalamic nuclei-lesioned rats. | Rats with dorsomedial hypothalamic nuclei lesions (DMNL) are hypophagic and have reduced linear and ponderal growth, but have normal body composition and anabolic hormone concentrations. Previous studies have shown rats pair-fed to levels consumed (70-80% of ad lib) by DMNL rats, using a meal-feeding paradigm, have abn... |
8044684 | Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia. | The effects of the selective kappa-opioid, PD117302 ((+/-)-trans-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]benzo[b]thiophene-4-acetamide), on transient (15 min) global forebrain ischemia, induced by four-vessel occlusion, was evaluated using a multiple fixed-ratio, fixed-interval schedule of food presentation in rats. ... |
8044683 | Interleukin-2 does not cross the blood-brain barrier by a saturable transport system. | Blood-borne interleukin-2 (IL-2), like other cytokines, is known to affect the central nervous system (CNS). One mechanism by which circulating substances can alter brain function is to directly cross the blood-brain barrier (BBB). We investigated the ability of IL-2 to cross the BBB, the interface between the peripher... |
8044682 | Processing articles and pronouns in agrammatic aphasia: evidence from French. | The hypothesis that closed-class items which participate in theta-role assignment are less problematic in agrammatism than items which do not (Rizzi, 1985) is put to an empirical test. Five French-speaking agrammatic patients were tested in a sentence-picture matching paradigm to probe their comprehension of sentences ... |
8044680 | Patterns of recovery and change in verbal and nonverbal functions in a case of crossed aphasia: implications for models of functional brain lateralization and localization. | We present a 2-year verbal and nonverbal follow-up of a crossed aphasic patient. The patient had suffered from widespread ischemic damage in the area of right middle cerebral artery, with a parieto-temporal lesion. Three months postonset he showed classical Wernicke's aphasia associated with oral, limb and construction... |
8044681 | Is speech temporally segmented? Comparison with temporal segmentation in behavior. | Phrase durations in spoken German and Korean were examined for temporal segmentation like that in behavior. Lines of poetry, which may be regarded as semantic units equivalent to action units in behavior, were found to be temporally segmented but, unlike behavior, there is a significant effect of language/culture on se... |
8044679 | Right hemisphere involvement in processing later-learned languages in multilinguals. | In two experiments, multilingual Papua New Guinean subjects were tested using a divided visual field technique designed to determine hemispheric laterality for English and for Tok Pisin. Various factors including age of acquisition, proficiency, mode of instruction, and number of years that the language had been used w... |
8044678 | Influence of language structure on brain-behavior development. | Lack of exposure to specific sensory patterns during critical periods of development can result in a lack of responsiveness to those stimuli in adulthood. The present study extends these observations to native speakers of Japanese, a language which does not contain the contrastive /r/ and /l/ sounds present in English.... |
8044677 | Language function in delirium: a comparison of single word processing in acute confusional states and probable Alzheimer's disease. | Thirteen patients suffering from transient acute confusional states (ACS) and 11 patients with probable Alzheimer's disease (AD) who were comparable for age and Mini-Mental State score were investigated with a naming and a comprehension task. The latter included both words that were previously included in the naming ta... |
8044676 | Quantitative and qualitative evaluation of patterns of cerebral language dominance. An amobarbital study. | As a part of presurgical evaluation, 173 patients received bilateral intracarotid amobarbital tests for determination of cerebral language dominance. Language testing during intracarotid amobarbital procedures (IAP) consisted of the following tasks: automatic speech, sentence comprehension, body commands, naming, repet... |
8044675 | Hemispheric asymmetry for processing unpronounceable and pronounceable letter trigrams. | In each of two experiments, observers attempted to identify three-letter strings presented briefly to the left visual field/right hemisphere (LVF/RH), to the right visual field/left hemisphere (RVF/LH), or to both visual fields (and hemispheres) simultaneously (redundant BILATERAL trials). Similar visual half-field eff... |
8044674 | On-line sensitivity to subject-verb agreement violations in Broca's aphasics: the role of syntactic complexity and time. | This study examined on-line sensitivity to subject-verb agreement violations in patients with Broca's aphasia and age-matched controls using a word monitoring paradigm. The agreement violations were couched in either simple or complex syntactic frames. In a first experiment, these syntactic frames were immediately foll... |
8044673 | Phylogeny through brain traits: more characters for the analysis of mammalian evolution. | We have assembled data on nine brain traits, in addition to the fifteen we have previously described, which provide new evidence for assessing mammalian relationships. States of these characters are tabulated as they occur in each of 152 mammalian species, providing data in numerically ordered form, useful for multiple... |
8044672 | Projection of brain stem neurons to the giant electromotoneurons in the cervical spinal cord of the electric catfish Malapterurus electricus. | Two giant electromotoneurons located within the cervical spinal cord form the centerpiece of the electromotor system in the electric catfish Malapterurus electricus. The cytoarchitectural organization suggests a high degree of input convergence onto the electromotoneurons. In order to obtain insights into the connectiv... |
8044671 | Are neuromotor systems conserved in evolution? | Hypotheses that neuromotor systems are conserved during evolution are examined. Focus is on the fundamental assumption underlying such hypotheses, that neuromotor patterns are homologous. The criteria for testing hypotheses of homology are briefly reviewed and applied to several cases in which neuromotor conservatism h... |
8044669 | Rotavirus infection in calves, piglets, lambs and goat kids in Trinidad. | Faecal samples from diarrhoeic and non-diarrhoeic calves, piglets, lambs and goat kids were collected and screened by a latex agglutination test to detect the presence of group A rotavirus antigen. Of a total of 470 animals screened, 138 (29.4%) had faecal samples positive for rotavirus antigen. The prevalences of infe... |
8044667 | Plasma enzymes and metabolites as potential prognostic indices of ovine pregnancy toxaemia--a preliminary study. | Three ewes with naturally occurring pregnancy toxaemia and increased plasma glucose concentrations within 24 h of the onset of clinical signs, made a complete recovery following treatment with a concentrated oral rehydration solution. Four ewes in which plasma glucose concentrations fell did not recover. Ewes with elev... |
8044668 | Proximal suspensory desmitis in the hindlimb: 42 cases. | Proximal suspensory desmitis of the hindlimb was diagnosed using local analgesic techniques and ultrasonography in 42 horses. Subtarsal analgesia resulted in substantial improvement in lameness in 36 of 41 horses in which local analgesic techniques were used. In the remaining five horses lameness was improved by perine... |
8044665 | Flunixin in the cat: a pharmacodynamic, pharmacokinetic and toxicological study. | There are relatively few non-steroidal anti-inflammatory drugs (NSAIDs) for which basic pharmacokinetic and toxicological data are available in the cat. This paper describes some pharmacokinetics and pharmacodynamics of flunixin in this species. Six healthy adult female cats were given 1.0 mg kg-1 flunixin meglumine or... |
8044666 | Antimicrobial susceptibility of Streptococcus suis isolates. | The antimicrobial activities of penicillin (PEN), ampicillin (AMP), cephalothin (CT), trimethoprim-sulphamethoxazole (TMP-SMX), streptomycin (STM), and gentamicin (GM) against 122 representative strains of Streptococcus suis, were compared by the agar dilution procedure. The current US National Committee for Clinical L... |
8044664 | Thermoregulation in the horse in response to exercise. | Conversion of stored energy into mechanical energy during exercise is relatively inefficient with approximately 80% of the energy being given off as heat. Relative to many species the horse suffers an apparent disadvantage by possessing a high metabolic capacity yet a small surface area for dissipation of heat, particu... |
8044661 | Counselling following diagnosis of fetal abnormality: a comparison between German, Portuguese and UK geneticists. | The principle of non-directiveness in genetic counselling is embraced by all relevant professional bodies. Little is known about the extent to which it is endorsed by geneticists, or incorporated into their clinical practice. The aim of the current study is to document how geneticists in three European countries, Germa... |
8044660 | A systematic search for uniparental disomy in carriers of chromosome translocations. | A systematic search was made for uniparental disomy in carriers of apparently balanced chromosome translocations who also had unexplained abnormalities of mental or physical development. Of 65 families studied, biparental origin of both translocated chromosomes was demonstrated in 64, and only 1 case of maternal unipar... |
8044659 | Difference in frequencies of the cystic fibrosis alleles, delta F508 and W1282X, between carriers and patients. | One major mutation, delta F508, causing cystic fibrosis (CF) is found in most populations around the world. Among CF patients of Jewish Ashkenazi origin two major mutations, W1282X and delta F508 were found. We compared the relative frequencies of the two major mutations found in this patient population to their relati... |
8044658 | Assignment of granular corneal dystrophy Groenouw type I (CDGG1) to chromosome 5q. | Granular corneal dystrophy Groenouw type I (CDGG1) is an autosomal dominant disease with complete penetrance. 124 blood samples were collected from a single Danish pedigree of seven generations. Linkage was discovered with markers on chromosome 5q, with IL9 (Z = 15.96; theta M = 0.027, theta F = 0.00) and D5S436 (Z = 1... |
8044657 | Transition from normal to premutated alleles in fragile X syndrome results from a multistep process. | In fragile X syndrome, the most common cause of inherited mental retardation, phenotypic expression has been linked to a region containing a repetitive sequence, (CGG)n, that appears to lengthen dramatically in fragile X patients and to show length variation in normal individuals. In order to investigate possible mecha... |
8044656 | Mutations in the muscle sodium channel gene (SCN4A) in 13 French families with hyperkalemic periodic paralysis and paramyotonia congenita: phenotype to genotype correlations and demonstration of the predominance of two mutations. | Hyperkalemic periodic paralysis (hyperPP), paramyotonia congenita (PC) and PC with myotonia permanens are closely related muscle disorders of genetic origin due to allelic mutations in the muscle sodium channel gene, SCN4A. Seven families of French origin with hyperPP were studied. Five of these had the Thr704Met mutat... |
8044655 | Strong founder effect for the fragile X syndrome in Sweden. | We analyzed the FRAXAC2 and DXS548 microsatellites in normal and fragile X chromosomes from Sweden and the Czech Republic in order to investigate a possible founder effect for chromosomes carrying a fragile X mutation. We report a much stronger linkage disequilibrium between the marker haplotypes and the disease in Swe... |
8044654 | DNA diagnostics of the Marfan syndrome: application of amplifiable polymorphic markers. | The diagnosis of Marfan syndrome (MFS) is still based on careful clinical examination. There are, however, many factors creating problems in the firm establishment of the correct diagnosis. After the identification of the defective gene in MFS, fibrillin 1 (FBN1), several mutations in this gene have been reported. Sinc... |
8044653 | Limited expansion of the (CAG)n repeat of the Huntington gene: a premutation (?). | Huntington's disease (HD) is an autosomal dominant disorder with choreic movements, psychiatric manifestations and cognitive dysfunction. Recently the IT15 gene on chromosome 4p has been identified containing an unstable and expanded trinucleotide repeat in patients with HD. We report on the characteristics of this rep... |
8044652 | The 8993 mtDNA mutation: heteroplasmy and clinical presentation in three families. | The point mutation at bp 8993 of human mtDNA in the ATPase 6 gene is associated with neurogenic weakness, ataxia and retinitis pigmentosa, and with subacute necrotizing encephalomyelopathy (Leigh disease) when present at high copy number. In this study we describe three new multiplex families with the ATPase 8993 mtDNA... |
8044650 | A simple method for prenatal diagnosis of trisomy 21 on uncultured amniocytes. | Prenatal diagnosis of trisomy 21 would be easier if fluorescence in situ hybridization (FISH) could be applied to interphase nuclei. Therefore, we prepared a chromosome-21-specific probe by in vitro enzymatic amplification of inter-Alu sequences from YAC clones previously localized to this chromosome. This probe was us... |
8044649 | Screening for carriers of cystic fibrosis among pregnant women: a pilot study. | Cystic fibrosis (CF) is one of the most common hereditary disorders among Caucasians. In such populations a highly prevalent mutation causing CF, delta F508, has been identified. It comprises 88% of Danish CF mutations. This mutation and five others account for 90% of all CF mutations, making carrier screening on a pop... |
8044648 | Collaborative study of the molecular epidemiology of Tay-Sachs disease in Europe. | Tay-Sachs disease is a lipidosis due to the deficiency of the lysosomal hexosaminidase A. In order to understand the molecular mechanisms of this enzyme deficiency we studied 42 patients of different ethnic origins diagnosed in Europe. The strategy used consists in HEXA cDNA amplification followed by allele-specific ol... |
8044647 | A five-year prospective study of the health of children in different ethnic groups, with particular reference to the effect of inbreeding. | A 5-year prospective study of 4,934 children of different ethnic groups has demonstrated a 3-fold increase of postneonatal mortality and childhood morbidity in the offspring of consanguineous Pakistani parents. Most of these families contained more than one consanguineous union, resulting in a mean inbreeding coefficie... |
8044646 | Testing genomic imprinting in Wilm's tumor. | Data from 511 cases of Wilms' tumor in France (including 12 familial cases) and 8 pedigrees from the literature were analyzed to test three modifications of Knudson's classical bimutational theory, based on genomic imprinting in Wilms' tumor carcinogenesis. Analysis of data of age at diagnosis and segregation analysis ... |
8044645 | Striking founder effect for the fragile X syndrome in Finland. | The fragile X mental retardation syndrome is caused by the expansion of an unstable CGG repeat in a 5' exon of the FMR1 gene. Significant linkage disequilibrium between this mutation and flanking microsatellite markers has been observed previously in Caucasian populations, a very unusual finding for an X-linked disease... |
8044642 | Post-emergency epidemiological surveillance in Iraqi-Kurdish refugee camps in Iran. | In 1991 a computerized, comprehensive epidemiological surveillance system was developed to monitor health trends in approximately 25,000 acutely displaced Kurds in Nowsood and Saryas refugee camps, Bakhtaran region, Northwestern Iran. In addition, community-based surveys offered information unobtainable from health fac... |
8044641 | Military participation in emergency humanitarian assistance. | Military forces of the United States and other countries possess training, equipment and capabilities that are suited for work in disaster preparedness and assistance. Information on the use of military units in domestic and foreign disaster-related efforts, particularly by United States forces in the medical area, was... |
End of preview. Expand in Data Studio
18.86M PubMed Titles and Abstracts
- Downloads last month
- 102