Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
A0A1U8KI70
3.1.1.11
ACT_SITE 418; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MNESKEILTKNFDSVKHISSTKRHKKIFLAVLACLVIVAALIGIVAKENSRNKFDETNESHHAIVKSACSSTFYPDLCFSAVAAAAAAKKVTRKKDVIRLSLNITASAVEHNFYKIKKLLARKGLTERGVTALHDCLETINETLDELHQAVEDLHGYPYKKPLTQHADDLKTLISAAMTNQETCLDGFSHKNADKEVRKALIDGEKYVEKMCSNALAMIKNMTDEDIANEMLIKRSNRKLEEEGNGIGWPRWLSTGDRRRLRSSSVIPNVVVVADGSGDYKTVSEAVAKAPVNSRKRYIIRIKAGVYRENVEIPSNKTNIMFIGDGRSRTVITGKRNVVDGSTTFRSATVAVAGEGFLARDITFENTAGPSKHQAVALRVSADLTAFYQCNMIAYQDTLYVHSQRQFFVNCLITGTVDFIFGNAAAVFQNCDIRARRPHRGQKNMVTAQGRTDRNQNTGIVFQKCRIGATSDLQSVKNKFPTYLGRPWKEYSRTVILQSDISDVIHPAGWHDWNGSFALKTLFYGEYQNTGASAGTHARVKWDGHKVITNESEAQSYTAGEFISGGSWLYSTGFPFSLDL
125
A9UVV1
2.3.1.286
ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
MAATKLHPALRNAIRAGANLPTEVISATFDVQEGIKLLSAFLLRHEPVCVLTGAGISTDSGIPDYRSPGRPPHRPLQHLEFLGSHERQQRYWARSLYGYPRIRDTMPNVGHQAINELQRRGLVGAIITQNVDGLHQRAGSQHVIDLHGRLDQVKCMNCHSITTRDELQSRLLADNKALLDQFSVVHDEAVRPDGDAVLDEDLYGRFTVAACASCGGVLKPNVVFFGGSLDPEDVKRASTAVSEASALFVVGTSLATWSAFRIVRQAVEEAKPVCVLNSGPTRADGVIPEYLRLCMPIGEVLPAALRQL
58
Q0TX23
3.5.1.2
ACT_SITE 81; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 194; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 196; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 240; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 400; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"
MPTVHLLDYVAGNVRSLVNAIEKVGYTVEWVKSPADLPSAEKLIIPGVGHFGHCLSQLEKAGYVEPIRQHIKAGKSFMGICVGIQALFEGSEEDPNVKGLGIIPSQLKKFDDKDKSVPHIGWNSANTSRTGQATDDSFYGLRPTSKYYYVHSYAAPYEEGRLEKLGWTVATARYGDEEFIGAVARDNVFATQFHPEKSGAPGLRVLKAFLEGTRSQKLPKQLSAGDTKEGLTRRVIACLDVRTNDQGDLVVTKGDMYDVREKKGAGNAVRNLGKPVEMAKKYYEQGADEVTFLNITSFRNCPVADIPMLEILRQTSETVFVPLTIGGGIQDTVDVDGTKISALDIATMYFKSGADKVSIGSNAVIAAEEYYARGSKLAGNTAIETISSAYGNQAVVVSVDPKRVYVQSPESTPHHAIKTSRPGPNGEEYCWYQCTIKGGREGRDFDVRQLVTAVEAMGAGEILLNCIDQDGSNSGFDLELINDVKDAIKIPVIASSGAGNPGHFEEVFARTRTDAALGAGMFHRGEYTVKQVKDHLQEKGLVVRPFEADI
181
A0A251V3B4
3.1.1.11
ACT_SITE 356; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKTLLFLATFLVGLYHSCVYGDTKSEITSWCNQTPHPQPCQHFLTTNSNHGPINQKLDFVKALLRVTLDHAQHAMSHTQTLGSKCRNDYEKAALADCLELYEDTIMNINKTVDPNHKCSQVDTQTWLSTALTNMDTCKAGFEELGVNNNVWSLMGNNVSSMISNTLAMNEGGESFNNGAPSPQILGFPSWVKPGDRKLLQSKTPKADVVVDKGGSGDYKTIGAAIAAAGKRSGSKRYVIHVKAGVYKEYVDIGSKVKNIMLVGDGIGKTIITGSRSVRGGSTTYKSATLAVLGDGFICRGITIKNTAGPKSQAVAVRNNSDLSVFYQCSFEGYQDTLYVHSNRQFYRQCDIYGTIDFIFGNAASVLQNCNIYSRKGPTKTNTLTAQGRSDKNQNTGISIHNCRITAAPNDPNSVPAVRTYLGRPWRQYSRTVVMKSNLDNLIDPAGWMSWGDDNALKTLYYGEYKNTGPGSSTSKRVDWKGYHVITSSTEATKFTVGKFIVGGYWLPVTNVPFTSGL
125
Q8IQM5
2.3.2.23
ACT_SITE 125; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133"
MTTAASTSQHATSSSTMMAGSGSLATSSSAAAPTTTPSSSAVRALAMEYKSLQEEPVEGFRVKLINDDNLFEWEVAIFGPPDTLYQGGYFKAHMKFPHDYPYSPPSIRFLTKVWHPNVYENGDLCISILHPPVDDPQSGELPCERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRRWRDSQDNEYPNIIRKQALAANAEAKREGIVVPMTLEDYCLKPTRKPTTESGLDANFYDDDFDLETEDDLPSDDDFDEDDDDDEDEDEDEDSATAPISKNNGGSSKCKNNGLVREAAAAGADDAESADDSGKGETT
64
A0A8M1RHB8
2.7.10.1
ACT_SITE 672; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50"
MDVWLCSAVPVFTWRLFFLSSIFQGYWSSMLDCPPTCSCSPTEIYCNKSDVGNFFPLLALQESAGNGSNNNDIEELFRNITSIHIENWTGLQILRDVDMELYTGLQRLTIINCNLRQIQPRAFSRNPHLRYINLSRNPLASLSWQLFQHLQLVELRLEGVVFDCGCKIRWIQLWRLRGEAGLHTQQLYCKDGASKISLRSMSIAHCDLQDISVAHSNLTVLEGGNVTLSCNGSGSPVPEVDWAVKGLHSINTHQSTVYLPNTHSINLTLVNVSRDDNGFVLTCISENVVGMNNVSLQLSVLFPPVILKLDEPERRHHTCIEFTVRGFPHPTLHWFYKGREILQSEYIRMEMDYYKDYLEGCLTFENPTHYDNGNYTLVATNSLGSVSKTVFGHFLDPPFMEDDGIMEYTPPPEDEGKRPEDSFGMSIAVGLAGFGCVFLIVIFVLINKYSRRNKFGIKGPVAVISGEEDSASPLHHVNHGIVTPCSLDAGPDAVVIGMSRIPVIENPQYFRHGHNCNKPTTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLTARKDFQREAELLTNLQHEHIVKFYGVCVDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPMQSNGELGLSQMLHIATQIAAGMVYLSSQHFVHRDLATRNCLVGNGLLVKIGDFGMSRDIYSSDYYRVGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVIMWEIFTYGKQPWFHLSNNEVIECITQGRVLDRPRLCPKEVYDLMLGCWQREPQQRLNIKDIQKVLYALGKATPVYLDILG
97
P9WHP9
5.4.99.12
ACT_SITE 72; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171"
MSLTRRPPKSPPQRPPRISGVVRLRLDIAYDGTDFAGWAAQVGQRTVAGDLDAALTTIFRTPVRLRAAGRTDAGVHASGQVAHVDVPADALPNAYPRAGHVGDPEFLPLLRRLGRFLPADVRILDITRAPAGFDARFSALRRHYVYRLSTAPYGVEPQQARYITAWPRELDLDAMTAASRDLMGLHDFAAFCRHREGATTIRDLQRLDWSRAGTLVTAHVTADAFCWSMVRSLVGALLAVGEHRRATTWCRELLTATGRSSDFAVAPAHGLTLIQVDYPPDDQLASRNLVTRDVRSG
217
Q9UXF3
3.4.25.1
ACT_SITE 15; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113"
MGNELQLENKILKGTTTVGIRVNDGVILAADRRASAGFFVANKMVRKVLYITDKIGITTAGSVADLQFIYDVLKNIYHYNSITKYGPISIKGIATRLANVLSATKYFPYIVQILIGGYDDQPRLFNLDYLGDITEENYVATGSGSPVAMGVLEDEYNPKMTLDEAADLAKRAVFSAIKRDSFTGTGVIVAKIHSKGHEELEFYLNKKM
180
Q81GJ9
2.7.1.23
ACT_SITE 45; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361"
MKFTIMSKGDQSSDTLASTMKEYLLDFGFIMDEKEPDIVISVGGDGTLLYAFHRYYNRLDETAFVGVHTGHLGFYADWLPTEVEKLVIAIAKTPFQVVEYPLLEVIIRYVNGSKESQYLAMNEATVKSAEGTLVTEVEIRGEYFETFRGDGLCISTPSGSTAYNKALGGAIIHPSIEAIQIAEMASINNRVFRTVGSPLVLPKHHTCVLKPAAGMNLQITVDHLTMVHQDVKSIQYRVANEKVRFVRFRPFPFWKRVRDSFVADK
89
U5D4A7
3.2.1.52
ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MNLHYIPNALCSLSSLILLLFISSIPTSIAQPPQVLVWPKPRNLTWTPPYSSILLSPTFTISYSGSNPYLQNAVSRYLRLILAEKYTPVRPIPSNLTASTQPLQTLTLSVNDETPPLQHGVDESYSLSIPNGTAVLWSATVWGAMRGLETVSQLVWGDPARLPVGLEIWDSPLFEHRGVMLDTSRNYYGMREILRTIGAMSENKMNLFHWHITDSHSFPIVLPSVPELAEKGSYGAGMQYSAEEVRGIVEFGMSRGVRVVPEIDSPGHTGSWAAAYPEIVACANMFWSPPGKDPLAAEPGTGHLNPLHPNTYPLLRNVLRDLAALFPDSFLHAGADEVIPGCWKADPKIQAFLASGGTLSQLLETHVNATQPYIESLNRTAIYWEDVLLDSTINVKPELLSKETTILQSWNNGPNNTKLITSMGYRAIVSSSAFYYLDCGHGDFLGNDSSYDKMGDEGNGGSWCGPFKTWQRIYDYDITYGLTAEEAKLVLGGEVALWSEQADGTVLDPRLWPRTAAFAEAMWSGNRDETGIKRYAEATDRLNEWRYRMVARGVGAEPIQPLWCLKNPGMCNLSQ
170
A0A8I6X1C7
2.2.1.1
ACT_SITE 499; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MLQEGSSGDVEVARGSTASPVHDQLPHRHRHRRGHSSQTQPATTMATPTPAPMSPASKAAALASGGFLVGRARVSLGRRPALRAQPAAAELVERSVNTIRFLAVDAVEKAKSGHPGLPMGCAPLGHVLFDEFLRFNPANHAWFDRDRFVLSAGHGCMLHYALLHLAGYQGVTIDDLKAFRQWGSRTPGHPENFETDGVEVTTGPLGQGFANSVGLALAEKHLAARFNKPDLTVVDHYTYVILGDGCQMEGVANEAASLAGHWGLGKLIAFYDDNHISIDGSTAIAFTEDVLARYEALGWHTIWVQNGNTGYDDIRAAIKEAKEVKDKPTLIKVTTTIGYGSPNKASTHSIHGSALGSKEVEATRKNLSWAHEPFHVPDEVKRHWAHHLDEGASLEAEWNAKFAEYEKKYQQEAAELNSIISGRLPAGWEDALPKYTRESPADATRNLSQQCLNALAKVIPGFLGGSADLASSNMTLLKMFGDFQKDTPEERNIRFGVREHAMGAICNGIAVHSPGLIPYCSTFFVFTDYMRASIRLSALSESGVIFVMTHDSIGLGEDGPTHQPVEQLFSLRAMPGILMLRPADGTETSVAYRIAVMNRKRPSILALSRQKLPQLEGTSVEGVAKGGYVISDNSSGNKPDLILIGTGSELEIADKAAEQLRKEGKFVRVVSLVCWELFEEQSEEYKESVLPSEVTSRISIEAGVTLGWEKYIGQKGKAIGIDRFGSSAPAGKIYKEFGLTVDNLIATAKSL
51
A0A9R1XR71
2.7.1.11
ACT_SITE 306; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MGSLSPSINPRLVSQANSYDLVSFRRVFGPVLTGPQARPDMTGACRRSRRRAVYAKKNANEDFVNCDSEWKSKFKEDFEKRFNIPHISDFFPDAASYPSTFCLSMRTPINEEFAEGYPSDEEWYGYINNDDRVLLKVIRYSSLSSAGAECIDPDCTWVEQWIHRAGPREKIYFKPENVKAAIVTCGGLCPGLNDVIRQIVITLEIYGVKKIVGIPFGYRGFGKEIDEIPLSRKVVQNVHLSGGSLLGVSRGGPSLDEIVDSMEDRGINMLFVLGGNGTHAGANLIHNECIKRGLKVAVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINAAYIEAHSAYRGIGIVKLMGRSSGFIAMHASLASGQIDICLIPEVPFELQGSHGVLNHLKYLLETKGSAVICVAEGAGQSFLEKTNAKDASGNVVLGDIGVHIQQEVKKYFKEMGNPTDVKYIDPTYMIRACRANASDGILCTVLGQNAVHGAFAGYSGITVGICNTHYVYLPITEVISYPKIVDQNSRMWHRCLTSTGQPDFL
84
A0A9J7HNL2
2.3.1.181
ACT_SITE 180; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1"
MNRVLYVRNLGRISYSEGLRAQEQLQRQHLDGLAGKTSEPAKDTLLLCEHHPVYTTGHRTGQYSDSEEDRLKKLGAEFHRTNRGGLITYHGPGQLVVYPVINLAHFRKSMKWYICQLEKSVIRTCQSFGIQAQTSPDTGVWVGDRKICAVGVHGSRFITTHGFALNCNPDMTWFRHIVPCGIVGKGVTSLSMELGYNIKIQDAIPTMVASFAAQFDCSEVLHLDQNVPTGRNSEDEASCSTV
55
A5I7R5
3.1.1.29
ACT_SITE 19; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083"
MYLVVGLGNIGKEYKKTRHNIGFDVVDIIAEKYNIEINRQKFKGSYGEGRIGNEKIILLKPSTYMNLSGESVIEAANFYKIDKENIIVIYDDMSIDIGKLRVRSKGSAGGHNGIKNIIQHLNSDIFPRVRVGIGQPDENVVNYVLGKFSKDEREIIEKVLAMSAKACISIVEDGVTEAMNKYNGVKIEV
127
Q74AX1
3.1.26.3
ACT_SITE 62; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 134; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"
MRETDEQPVAGGAASTEGLETSIGYRFTDRRFLDEALTHRSWLNEVRSPTVPDNERLEFFGDAILGFCIGKMLLRHYPESREGALARMKSALVGEETLADLAAAVELGSYLRLGRGEERSGGRHRRSLLANALEALLAAMYLDGGMAPVERLVDAWFGPRLAGVAAGIKGRDFKTDFQELAQAQYGGLPRYVLVDTSGPAHDLRFTVAAYVGERLLGQGTGRSKKEAEQAAARQCLERLETGRCSAAP
138
Q74CQ6
2.7.7.7
ACT_SITE 106; /evidence="ECO:0000256|HAMAP-Rule:MF_01113"
MSNHRTILHLDMNAFFASVEQQADPSLQGKPVAVIGSGARTIITTASYEARAHGVGTGMTTHEAKRLCPELILVIGNNREYTRISKLIFEMLGQFTPLVEVFSIDEAFLDLTGSLRLFGRADVIAREIKARIRDRFGLTCSIGIAPNKLLAKLASDMQKPDGLTIIPPENVASLMKTTPIRSLCGIGPSTEQRLKYLGISTCNDLGHFSSKILTRHFGAMGARLKQMGQGIDDSPVIPTTTEEEVKSVSHSTTLDHDLTNKDDIHKYLLMLSEMVGRRARRYKTKGKTVTLTIRYADFTTFSRQETLPSPLNRSGDIYRAVTALLDTLQLTQPIRLLGVAISNLVHASEQLPLFPEERRLTTLSQAMDQVNDRFGETTITFGTLLGQDNCSHVIAPAWRPAGIRDVKVK
121
Q838S2
3.2.1.14
ACT_SITE 161; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258"
MKLKKIIPAFPLLSTVAVGLWLTPTQASADAADTMVDISGKKVLVGYWHNWASKGRDGYKQGTSASLNLSEVNQAYNVVPVSFMKSDGTTRIPTFKPYNQTDTAFRQEVAQLNSQGRAVLLALGGADAHIQLVKGDEQAFANEIIRQVETYGFDGLDIDLEQLAITAGDNQTVIPATLKIVKDHYRAQGKNFIITMAPEFPYLKPGAAYETYITSLNGYYDYIAPQLYNQGGDGVWVDEIMTWVAQSNDALKYEFLYYMSDSLIHGTRGYLQIPNDKLVLGLPANRDAAGSGYVVEATPVAKTFDQLAKDGNPIRGLMTWSANWDVGQDVNGKSYNNEFATRYSNLVK
158
Q8GY91
1.11.1.11
ACT_SITE 123; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297, ECO:0000255|PROSITE-ProRule:PRU10012"
MTTTTASLVKTFLFRCDSFSSFKFKCKFESPAKTRLLSPATEKHVVRSSRAWRIRCLSDDPGSSHVFVASRRKMVVLLSTVQLLSHMLPQNGNAAEIYPVMQNEIRKVVTKGKAAGVLRLVFHDAGTFELDDHSGGINGSIAYELERPENIGLKKSLKVLAKAKVKVDEIQPVSWADMISVAGSEAVSICGGPTIPVVLGRLDSAQPDPEGKLPPETLSASGLKECFKRKGFSTQELVALSGAHTIGSKGFGDPTVFDNAYYKILLEKPWTSTSKMTSMVGLPSDHALVQDDECLRWVKRYAEDQDKFFEDFTNAYIKLVNSGAKWNML
11
Q54SC9
3.2.1.52
ACT_SITE 314; /note="Proton donor"; /evidence="ECO:0000250"
MINKFLTIFLIFSIVIIKVLSQSSNEQPLNVVPYPQEVTMIGCNIPLSVGSISIKSNIESTILSISISRYQSLFFPFVSNNVLKDSSSNIELSLIIASDDETLELGIDESYFLLVNQDTYQIKANTIYGAMRGLETFKQMVVYDVVENSYSLTCAEVVDYPTYQWRGLLVDNARHFLPKNMVLHIIDSMGYNKFNTMHWHLIDTVAFPVESKTYPKLTEALLGPGAIITHDDILEVVAYAKTYGIRVIPEFDVPGHSASWGVGYPELLSNCPGYPQSSIPLDCSNPYTYSFLENFFSEIAPLFQDSYFHTGGDELVIDCWANDTSIQKWMKTNNYNTSDAFQYFEDQLDVILKSINRTKIAWNDVLQHGVKFDKETTLVQTWTNINDLRDVLAAGYKTITSFFFYLDRQSPTGNHYHYEWQDTWEDFYASDPRLNITSNAENILGGEATMFGEQVSTVNWDARVWPRAIGISERLWSATEINNITLALPRIGQFSCDMSRRGISSGPLFPDFCSLPDDLSFSFKPVYQLSKDEIKLILKKK
170
A0A397XIT6
3.1.1.11
ACT_SITE 381; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MHVMMHRIYFLSLYLISLLFLCLHPFTISADDNSTTGIDKWCNQTPYPDPCKCYFKNHNGFRLPTQLSEFRLMLVEATMDRAISARDELARSSGNCTDCRKQAVFADCINLYEDTIVQLTRTLAGVAPKAGAGKKCTDFDAQTWLSTALTNIETCRRGSSDLNVSDFITPIVSNTKISNLISNCLAVNGALLPTGNNSTTTADGKDFPTWVSGKERRLLQLQSARAVRANIVVAKDGSGQVTTVQAAIDVAGRRKLMSKRFVIYVKRGIYQENINVRLNNDNIMLVGDGMRSTIITGGRSVKGGYTTYNSATAGIEGLHFIAKGLTFRNTAGPAKGQAVALRSSSDLSIFYKCSIEGYQDTLMVHSQRQFYRECYIYGTIDFIFGNAAVVFQNCIILPRRPLHGQSNVITAQGRADPFQNTGISIHNSRILPAPDLKPVLRTVKTYMGRPWMKYSRTVVLQTYLDSVVSPFGWSPWIEGSIFGLDTLFYAEYKNSGPASSTRWRVRWNGFHVLKRASDASAFTVGRFIAGPAWLPRTGIPFTPGL
125
Q758T2
2.7.11.1
ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSAWASQEAAKEEEAVGDFARMLERRDAGLLARVLSRAQTGPEAYVRGLWRAEVGLERWRLTRVLGCGSVACVFELGDGALALKVPTSRRKAPVLLHEVLIYSHLAQQAGGRLAERHVVPFHGVAAVTRREYRRLRGGEVVPALVLERMDTTLEAVHRRAAVSKGQWWRYARDLVAALQFLRESCVVHGDIKTANVLVRGQDAFLADFTSAAVCDAAPEPLTTTLEYCAPGLIGGGQPTHSTDVYAAGLCLLALITRFEPFRELSMMKSHSSAPTHSLHETQWLMNAISKGDPIKYNVLSQDLYDRWAEELHFLRRFFVPAAQDALSRWLAESNARVAEHAF
99
F1SPM8
2.7.11.1
ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSFFSFKLLKKECPVPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRAMVQPPPQVAGSSNQPGLLASVPQPKTQAPPSQPLPQSQAKQPQAPPAPQQPPSAPAQGLPAQAQATPQHQQQLFLKQQPQPPQPQPQAQAPPVKSLKFYPFYPMCKGRQTVSSQFQAVHPAAQQPAIAQFPAVSQGSSQQQLIQNFYQQQQQQQQQQQLATTLHQQQLLTQQAALQQKTTVAAIQPPQAQPATASQPPPAQEPAQIQAPVRQQPKVQTTPPPAIQGQKLGSLTPPSSPKAQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRASQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQPTQGDAFAASSFAAGTAEKRKGGQAVDSSLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVASNRTDSLTGEDALIDCSLLSNPTTDLLEEFAPIAISAPAHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
99
A0A2C9W9K8
1.11.1.24
ACT_SITE 45; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MPGLTLGDAIPNLEVESTHGVIRLHDYIDTWTLLFSHPADFTPVCTTELGKLAAYAPEFSKRGVKLLGLSCGDVLSHVEWIKDIEAYTPGCKVTYPVIADPKRLVLHQLNMVDPDEKDPSGNNVPSRALHVVGPDKKIKMSFLYPASTGRNIDEVIRVLDSLQRAAKHNIATPVNWKPGDPVVISPNVSNDEAEKMFPQGYKIVDLPSGKEYMRLTNLD
12
Q81FY9
2.7.1.25
ACT_SITE 106; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_00065"
MDTNITWHTASVSKDERRVKNGHHSFVIWFTGLSASGKSTVANAVARKLFEKNIGNYVLDGDNIRHGLNKDLGFSESDRMENIRRIGEVAKLFVDQGAVVLTAFISPFRVVRKQVRDLLAADEFIEIFVKCPIEECEKRDPKGLYKKARKGDIKDFTGIDSPYEEPEQAELIVETHKYSIEECAEQIVKYLQERSFI
90
Q5AAH2
3.2.1.14
ACT_SITE 147; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258"
MILNLIILLAISIVASASNIAAYWGQNAGGDQQTLGDYCSSSPASIIILSFLDGFPNLSLNFANQCSGTFSSGLAHCSQIGSDIKSCQQQGKTILLSLGGATGNYGFSSDSEAVQFAGTLWNKFGGGKDSERPFDDAIVDGFDFDIENKDQTGYAALATQLRKYFSTGTKSYYLSAAPQCPYPDESVGDLMSQVDLDFAFIQFYNNYCSLNQQFNWNSWSNYARGKSIKLYLGLPGSSSSAGSGFVGLSTVQRVVASIKGDSSFGGISIWDISSAENGGYLNQLHQALSGSGSPAAPSNSYQPNTPLTRTYGGSTATASAYISVGFTAGATHGSTTTNDLLAWIDSLFGSSQSSVQQYATPVQSVTATPQPVAATTTSAPKPTASAFNWFGWFDGTTTSTTLQTVYSTVPADQTVYVTLTTTVGSQMLQSLFDKRDVIAEAKSTNLQICWLLFIPLLALICS
158
P51555
4.2.1.11
ACT_SITE 208; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P00924"; ACT_SITE 347; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P00924"
MSIQKVHAREILDSRGNPTIEVEITTGKGMFRSCVPSGASTGVHEAVELRDGDKKRYGGKGVLKAVENVNTIIGPALLGKNVLNQAELDEMMIKLDGTNNKGKLGANAILGCSMSICRAAAAEKGLPLYKYLAELTGHKEMTMPVPCFNVINGGAHAGNALAMQEFMICPTGATNFHEALRMAAETYQCLKVVIKAKYGQDATNVGDEGGFAPNVSGAREALDLLVEAIAKAGYTGKIEIAMDCAASEFYNEETKKYDLGKKIPADKKDPSLVKDVDGLIAEYVDYGKHYPIASIEDPFAEDDWAAWNKFTVEHGNFQIVGDDLLVTNPARVQMAMDKNACNSVLIKVNQIGTLTETFKTIKMAQEKGWGVMASHRSGETEDTFIADLVVGLNCKQIKTGAPCRSERLCKYNQLMRIEEELGNIPYAGKNWRNSTA
200
Q55BI3
3.4.19.12
ACT_SITE 131; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 134; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 239; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 316; /evidence="ECO:0000250|UniProtKB:Q96FW1"
MSLISIRIRSKTGVENIKLESQLKLKELQNIIEEKTKISTDTQKILYGFPPKALDLSNQDAVISGFLANGDTITIENVSSISSNPGVDSVTNDKVTSSTNSFDRNIKSQPFISQEEEEDGGYATRRVTDDDNSCLFSAVAYVLEDKNRLKGYSLRALIAQNVKSDPFEYNEAVLGKSNEGYCNWIQNPKNWGGAIELSILSNHYKVEIAAFDISTQLMYCYGEDRKYTERVYLIYDGIHYDALSICLTKNGPEDFDITRFSVDDKDSLAKMKVLIEKEFKAGKFTDTAKFSLICLNCNKTLKGEKEAAIHASTTGHGNFTEYKKR
175
Q8VXZ7
3.2.1.22
ACT_SITE 193; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P17050"; ACT_SITE 248; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P17050"
MVIMKKMKDSVLFLVVGLFSLSVLVSQSIAGRVKAPLLQSNTGGLVFSKSFNSIYDTSMYGRLQLNNGLARTPQMGWNSWNFFACNINETVIKETADALVSSGLADLGYIHVNIDDCWSNLLRDSEGQLVPHPETFPSGIKLLADYVHSKGLKLGIYSDAGVFTCEVHPGSLFHEVDDADIFASWGVDYLKYDNCFNLGIKPIERYPPMRDALNATGRSIFYSLCEWGVDDPALWAKEVGNSWRTTDDINDTWASMTTIADLNNKWAAYAGPGGWNDPDMLEIGNGGMTYEEYRGHFSIWALMKAPLLIGCDVRNMTAETLEILSNKEIIAVNQDPLGVQGRKIQANGENDCQQVWSGPLSGDRMVVALWNRCSEPATITASWDMIGLESTISVSVRDLWQHKDVTENTSGSFEAQVDAHDCHMYVLTPQTVSHSDV
162
Q9WZV0
3.5.4.5
ACT_SITE 56; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MVNPEKLVKMALEARKKAYAKYSGFRVGAALLTKSGKIYTGVNVENSSYGLTVCAERVAVFKAVSEGEREFVAIAIASDSPDKTAPCGACRQVLYEFSDDLDVIMADRDGNFEIVKLKDLLPRGFRLGGGEY
187
E3JS66
2.7.11.1
ACT_SITE 255; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MTSRVLQRGSQIDQIENSLSNVRLDESSKPKKKADTQNSNDQSVPGSFSAPKSFNQSKNKPYALAPPPSAPPISNPASLANMGIGQYDGGFERDEASGRGSWDPGHKPANDTLDFEIPSPLPKTQWSLNSFDIGRALGKGKFGRVYMVRTKAPPQFIIALKCLYKRELVECKVEKQLRREIEIQSNLRHPNILRLYGYFHDEKRIFLMLEYAGKGELYKQLHRHGKFSEKRSAKYIAQMADALHYLHRKHVIHRDIKPENLLLGVEGELKIGDFGWSVHAPGNRRKTLCGTLDYLPPEMVEGKDHNEKVDLWALGVLTYEFLVGVPPFEDLSGHNATYKKISKVDFSIPPTVSSEASDLIRKLLRHEPQDRLPLPQVANHPWILAHVRTRNGTSGGGSNTTKST
99
E3VWI2
1.2.1.12
ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362"
MTVRIGINGFGRIGRNVFRAAAARSSELEIVAVNDLGDVPTMAHLLAYDSILGRFPEEVTAEPGAIRVGDRTIKVLAERDPGALPWGDLGVDIVIESTGIFTDAAKARSHVDGGAKKVIIAAPASGEDFTVVLGVNDGDYDPERHTIISNASCTTNCLGVLAKVLHDAVGIDSGMMTTVHAYTQDQNLQDAPHKDLRRARAAALNIVPTSSGAAKAIGLVLPELAGRLDAFALRVPVPTGSVTDLTVTTRRGTSVEEVKEAYAAAASGPYKGLLSYVDAPLVSTDIVGDPASCVFDAGLTRVSGPQVKVVGWYDNEWGYSNRLIDLATLIGSSL
22
A0A251UJD6
3.4.21.92
ACT_SITE 126; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 151; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MPSVITRNLSKLWSGLPKTRTMASQRSSYSLIPMVIEHSSRGERAYDIFSRLLKERIICINGPIADDTAHVVVAQLLFLESENPSKPINLYINSPGGAVTAGLAIYDTMQYIRSPVNTICMGQAASMGSLLLAAGAKGERRALPNATIMIHQPSGGYSGQAKDISIHTKQIVRVWDSLNALYAKHTGQNIDVIQKNMDRDYFMTPEEAKEFGIIDEVMDERPITLVTDAVGTDGKGKECIWQKRTLTLQIQLRTKVNYMPSTYADLVNF
179
Q755Q5
2.7.1.11
ACT_SITE 346; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
MTMEVPLINGTNSVVVTAYSREQYAQCMQFYSAMLRLETLTKGENETVLTNKAVSVRVKYEEDKSRDQEARERREALAAAATTHDWRGEASTVVFSTVDVAKVRQTLGLCQAYPSELAPLEVYTLDPQGNVVGFTQTKNAISTFTNVPSVVGPRHARDSMTVSSAGSSTDLRSFGLDTTAHYPSLPKKSVAGDRKAIAVMTSGGDAPGMNANVRAIVRSVIFKGCRAFTVMEGYEGLVRGGPEYIKECKWEDVRGWSTEGGTNIGTARCMAFRERSGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIQELLETGKITQAQYDRYRHLNICGTVGSIDNDMSTTDATIGAYSSLDRICQAIDYLEATAKSHSRAFVVEVMGRNCGWLALMAGIATSADYILIPEKPASSREWQDQMCDIVSTHRSRGKRTTIVIVAEGAIAADLTPITPKDVHQVLVDRLGLDTRITTLGHVQRGGSAVAFDRILATLQGVEAVNAVLESTPDTPSPLIVLNENKIMRKPLMESVALTKSVADAIQAKDFKKAMGLRDPEFVEHLNNFMAINSADHDEPKLRGEKRLNIAIVNIGAPAGGINSAVYSMANYCLSQGHKPFAIYNGWTGLARHESVRTLNWKDMLGWQSRGGSELGTNRTVPEDADIGMIAYYFQKYKFDGLVIVGGFEAFVSLHQLERARENYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSAASTRARVFVVDVQGGNSGYLATHAALAVGAQVSYVPEEGISLEQLSQDIETLRESFEKAHGKGKHGKLILKSTNASKVFTTAVLADVITAEAKGDFDAKSAVPGHVQQGGLPSPIDRTRGTRLAVRAIGFIEAKQDVIREARENEEAFDCADKAVSHTAAVLGITGSQLKFTSIRQLYDLETEFSKRMPKVIHWEPTRAIADHLEGRKRVTV
84
Q383F3
1.1.1.37
ACT_SITE 189; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MSNTCKRVAVTGAAGQIGYSLLPLIAAGRMLGFDQRVQLQLLDISPALKALEGIRAELMDCSFPLLDGVVITDEPKVAFDKADIAILCGAFPRKPGMERRDLLQTNAKIFSEQGRVLGEVASPNCRVCVVGNPANTNALILLRESKGKLNPRFVTALTRLDHNRATAQVAERARARVEEVKNCIIWGNHSGTQVPDVNSATVGGKPARAAVDNGAFFDNEFITIVQERGAEIMKLRGLSSALSAAKAIVDHVHDWMLGTPSGTHVSMAVYSDGNPYGVPGGLIFSFPVTCSGGEWQIVSGLNVTPAISERIKATTTELEEERREVSTA
5
Q54F40
2.7.11.1
ACT_SITE 303; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MEPTYSIPSTPLKTPIRITVNNGHNSGQHSLSLSTCKPTPEQNAFNLNMFSEKKKNQYQTPKCPSPPLKSTPASRVNSNLPLIHHISSLSMFSPTTSLSDFMNCENGGSNNIDFSSSFGSSSLNSNNTLSINNNNNNNNNNGGYKIPSSVNKNSNNYNSNSNSNSSNNVISLFDKNFDVVCKLGSGSFSDVFKVKSKFDGNSYAIKQARHQFRGFQERERAVREVKAAVSLPPHTNVLQYYSSWEQNNTLFIQTELCENGSLQDFLDSLSPDQILSEELIWNFLLDVCLGIQHIHSYNMLHLDIKPENLFISSQGNIKIGDFGMAVKLETTNNNNNGNGGCQSNNTSMDSDCNNLSLDEDDIFFDFLEGDSRYLAYEFLLDKKQISKPSDIFSIGVTFFEMVTGNEMPTNGPLWEQLRSDKAIDFLEPGKYSDSLYQVILDMMKSNITERISLDQILLNENIQLVQQKRLNQFQNIDNIENDNNNNNNTDNNNNNNTDNINNDNNDDNNNNINNYNLKLITPYFQYQKERKDEELKEIIEFGEIREIKEKFEHHQFAIPTPHFVRSNAGRSSSSSLFSDEEEDDDDDDDSGRDSPIHFSLNNLNNSSSNIGISESNSNNSFSSILEENNESSSSSPLPSLSFSRRLSTSSLVTTISPKPNFNTSGNKLFSNENNNSNNNNNNNNNNQNNNNNNGFYGFTNNGSCNNLNNLNNLNSSGEFSNSSKKKLGKRGLPLLDVVNGGGNSGSKVCAIKRSFDSHPQESDKMSPRNLLSLFQETN
99
A0A8V0X5W9
2.7.10.2
ACT_SITE 1048; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1"
MATRVSRAQWAAAAEARLERKRGRNRKRKQDGSGKSAEPAMSLCRSAVSPPGATIFLHGGEDGGGEEQWWSDGSGAPSAEEICMELARRLGISPRCAALFALYDAPSRTWLPPNHRFDATEDCDRRLHFRIRFYFRNWHGMNEAEPTVFRHAPRHNESAGEKPRGTAVLDRASFLYLFEQGKFDFVNDAASLTDFRSEQEVQRFKNESLGMAVLHLCHIALRSGRCLEEVARKHSFKACIPRSFRLQIQQDSAVTRLRMKNVFRKFVRRFQRHTVGAGTLTEEDVMFKYLATLELLAPRFGTERFAALSLDVSNEGEKAQPYINGGHAMAEHGDAAVPGDCSVSHEVLVNGTGGIQWRPVPSESVEVISHRGYFGRRSRRKEPEPPAPPEPPWVHFCDFQEITHIVIEERRVSVHRQDNKCMEVLLPSHASALSFVSLLDGYFRLTADSNHYLCHDVAPPRLVMSILNGIHGPMQEEFVFAKLRREEHEEGLYVLRWSVLDFDRVILAVAKRDHQEDPGVPGALQFRQFRIQKKGSSFVLEGWEREFPTVRALLDALQGCTLRSGNDSFTVKRCCPPKPGEISDLLITTQKVKDNAKRILNLTQLSFHQIRKDEITQRAHLGQGTRTNIYDGVLNVRGAAGPDADEAEYFSTEQNNNSDGREMRVVLKVLDPTHRDIALAFFETASLMSQVSHVHLAFVHGVCVRGSENIMVEEFVEHGPLDVLLRKEKGRVPVGWKITVAKQLASALSYLEDKSLVHGNVCAKNVLLARTGLCDGTLPFIKLSDPGVSFTALSREERVDRIPWIAPECIQDVGNLHPAADKWSFGTTLLEICFDADVPLKERTPAEKERFYEKKHRLPEPSCQDLAALIQQCLSYTPAERPSFRTILRDLTQLQPHSLVDVSSVNPDLPVSDPTVFQKRYLKKIRELGEGHFGKVGLYCYDPTNDGTGEMVAVKSLKAGCSPQLLASWKKEIAILKTLYHENIVKYKGCCSEQGEQMVQLIMEYVPLGSLRDFLPRHHVGLPRILLFAQQICEGMAYLHSLHYIHRDLAARNVLLESDRRVKIGDFGLAKALPHGCDYYRVRDDGDSPVFWFAMECLKECKFSFASDVWSFGVTLYELLTHCHPALSPPAKFLEMIGATQGQMTVLRLMEVLESGRRLPCPNGCPCELYRLLQTCWDAAPAFRPTFPHLIPLLRSFRLRYGAAPPSVFSVL
98
Q8TIW3
2.7.7.7
ACT_SITE 115; /evidence="ECO:0000255|HAMAP-Rule:MF_01113"
MMQRVIIHVDMDYFYAAIEEREKPELLGKAVVVCMLSGRSELSGSVSTCNYIAREFGIRSGMPCSRAKKLNPEAVFLPVRKEFYTSVSDRIMEILRSYADPGENGDSFEQISVDEAFLEITYRAGGDFNLAFELGMQIKKEIKEKENLTCSIGIGPNKLIAKMASSAKKPDGITVVSPENQEAFLWPLKVSKLWGIGDVTAKKLQEMDIVTVKDLAEHDVIELISTFGKSRGTWLKQAASGIDDSPLKEREGSEQIGRIATLPEDTLDQELILSLLEKLAGDVIEKLDSRELSFRVVTVTVINSNFRTYTKSRTLNHPVSSKETLLEAAREILSEFLSESKTEFRRVGVRVGGLQKKKGQTSLFDY
121
C5YZJ3
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSRSTWLAFAWAAALVVVVVAASTTTTAHASHHASLEVGFYKHSCPEAESIVRDAVRRGVARDAGVGAGLIRMQFHDCFVRGCDASILINSTPGNKAEKDSVANNPSMRGFDVVDDAKAVLEAHCPRTVSCADIVAFAARDGAYLAGGLDYKVPSGRRDGRVSREDEVLDSNVPAPFDDVAELIQSFKRKGLTADDMVTLSGAHTIGRSHCSSFTQRLYNFSGQLGRTDPSLDVAYADHLKMRCPWPSSDGKRHPAVVPQDPVTPATFDNQYFKNVVAHKGLFVSDKTLLDSTCTAGIVHFNAAVDKAWQVKFAKAMVKMGKIQVLTGDEGEIREKCFVVNPH
14
Q751L7
6.3.4.2
ACT_SITE 404; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 535; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 537; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"
MKYVVVSGGVISGIGKGVLASSTGMLLKTLGLKVTSIKIDPYMNLDAGTMSPLEHGECFVLNDGGETDLDLGNYERYLGVTLTKDHNITTGKVYSHVMAKERKGDYLGKTVQVVPHLTNAIQDWLERVARIPVDDSGMEPDVCIIELGGTVGDIESAPFVEALRQFQFRVGRDNFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLTPDMIACRCSEELDKPTIEKIAMFCHVGPEQVVNVHDVASTYHVPLLLLEQRMIDYLGQRLKLSDIKLGAEDKERGARLLDRWRHLTTAIDESFEVVQIALVGKYTHLKDSYLSVIKALEHSSMRCKRKLEIVWVEASDLEPEMSASDKEKFQQAWKSLSSSDGILVPGGFGTRGTEGMILAAKWARENKIPYLGVCLGLQVATIEFARHVLGIADATSSEFYPEVAEDKQVVVYMPEIDKQNMGGTMRLGLRPTIFQEDTDWSIIRKLYGSASSVEERHRHRYEINPKMVQKLEEHGLKFVGRDETGTRCEILELVDHPYYVATQYHPEYMSKVLDPSQPFLGLVAAAANILPSLLAAERAVGARADF
252
B3S1G3
4.1.1.17
ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MSNPTIYYQLSKDKDDPFYIVNVGNILKKHKTWLSLLPRVEPFYAVKCNDDRNVLATLSALGIGFDCASMAEIKAVLKLGVPPSKIVYANPCKQASHLKFAAKREVSMMTFDNEPELHKVKQLHPTAKLILRLLTDDSKSLCRLGQKYGAPLKTVPNLLQVARNLDLNVVGISFHVGSGCYDASAFSSAVEIAKTAFDYGKSMGFQFDILDIGGGFPGSPRATVSFEEISATLNKALNKHFPVESGVRIIAEPGRYYVASAFNLAVNVIAKRQVNDDNTQAQGKQHAYRNQKYMYYVNDGVYGSFNCLLYDHAIVYPKTLGRDNEQQYSSSIWGPTCDGLDCVMKECMLPELDVGDWMYFEDMGAYTAAAASNFNGFQKPLAYYVIEEKVW
195
P29059
3.2.1.14
ACT_SITE 150; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022"
MRLLEFTALSSLLVLFLLLAVSAEQCGKQAGGARCPSGMCCSNFGWCGNTQDYCGPGKCQSQCPSGPGPTPRPPTPTPGPSTGDISNIISSSMFDQMLKHRNDNTCQGKSFYTYNAFITAARSFRGFGTTGDTTRRKREVAAFFAQTSHETTGGWDTAPDGRYAWGYCYLREQGNPPSYCVQSSQWPCAPGQKYYGRGPIQISYNYNYGPCGRAIGQNLLNNPDLVATNAVVSFKSAIWFWMTAQSPKPSCHDVITGRWTPSAADRAANRLPGYGVITNIINGGLECGHGSDARVQDRIGFYRRYCSILGVSPGDNIDCGNQKSFNSGLLLETM
158
B9R8G8
4.1.1.17
ACT_SITE 361; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MERSSGSLQVILDAPGVQGKTVTTLSKDSSNLTDYVESIIVNTQVNRESFYVLDLGAVAGLMHKWSRELPMIQPYYAVKCNSEISLIGALAALGCNFDCASKAEIQSILSLGVSPDRIIYANPSKPESHIIYAANVDVNLTTFDSKHELHKISKCHPKCSLLIRIKPPDDSGARWPLGSKFGALPEEIEPLLLAAQAAKLTISGVSFHIGSESRNPHAYRGAIGAAKHVFDTASRLGMPPMRVLNIGGGFIAGSNFDEAATVIKAALQDYFGDNPGIEIISEPGRYFAETVFMLATSITGKRVRGGIIEYWINDGVFGSFSCVIFGVSPPACVPLACTSNRANPKCKGEPTYKSTVYGPTCDAVDKVFVDQELPELEINDWLVFPYMGAYTTANATIFQGFSSEAIFTHLVYSNLI
195
Q9XG81
3.1.1.4
ACT_SITE 86; /evidence="ECO:0000255|PROSITE-ProRule:PRU10035"
MRFFLKLAPRCSVLLLLLLVTASRGLNIGDLLGSTPAKDQGCSRTCESQFCTIAPLLRYGKYCGILYSGCPGERPCDALDACCMVHDHCVDTHNDDYLNTMCNENLLSCIDRVSGATFPGNKCNVGQTASVIRGVIETAVFAGKILHKRDDGQ
130
P75949
3.2.1.52
ACT_SITE 176; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00364"; ACT_SITE 248; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00364"
MGPVMLDVEGYELDAEEREILAHPLVGGLILFTRNYHDPAQLRELVRQIRAASRNRLVVAVDQEGGRVQRFREGFTRLPAAQSFAALSGMEEGGKLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPQKALAIASRFIDGMHEAGMKTTGKHFPGHGAVTADSHKETPCDPRPQAEIRAKDMSVFSSLIRENKLDAIMPAHVIYSDVDPRPASGSPYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERGQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRQELMDSARWKAISTRLNQLHERWQEEKAGH
170
Q9RDN0
5.1.3.3
ACT_SITE 194; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 332; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MAATAVGGTAHASGGRKPVKELFGRLADGTKVYRWSLENGGTRMKVLSYGGVVESLEIPDRRGRYANVSLGFDNLDDYVARSPHFGALIGRYGNRIAKGRFTLDGKEYQLSVNDGENSLHGGALGFDYRVWDVEPFTHGSDTGLVLHYTSVDGEMGYPGTLRAKVTYTLTRRGDWRIDYEATTDKATVVNLTSHVYWNLAGEGSGTIEDHELSIAASRFTPTDAGLIPTGELARVSGTPFDFRRAKPIGRDIRDAHPQLVTAKGFDHNWVLDKGITDRPEHIATLRENASGRTLRIATDQPGLQFYSGNFLDGTLTGTGGSLYRQGDALCLETQHFPDSPNQPSFPSTVLRPGETYRTSTVHSFDA
211
A0A0K9NRU7
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MGYLGSCFLLFSVFITVSATVKNDSNGVGAGAGDGLVMNFYKESCPQAEDIIKEQVKLLYKRHKNTAFSWIRNIFHDCAVQSCDASLLLDSTRRHLSEKEADRSFGMRNFRYLNTIKEAVERECPNVVSCADILVLSGREGVAALGGPYIPLKTGRRDGYRSRSSSVLEEYLPDHNESISTVLEKFAAMDVDTPGLVALLGSHSVGRTHCVKLVQRLYPEVDPKLNPDHVPHMMKKCPDPIPDPKAVQYVRNDRGTPMILDNNYFRNILDNKGLLLVDHQIATDSRTRPYVKKMAKSQDYFFKEFTRALQILTENNPLTGTNGEIRKHCSFANKHHH
14
D7SYH1
2.3.2.26
ACT_SITE 1002; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MFFSGDSSTRKRVDLGGRSSKERDRQKLLEQTRLERNRRWWLRQQNSAALRIQKCFRGRKAVEAEHAKVREQFFTTYGRHCQNVDRHSFGPDSEFLRQLLFFFDARNVGDFSALVETCRLLQNFVRDSGDAVNLFAGMDYSSKNALVDYRVKQLAYACIQAVHQNRNQFKGQLLMTSDEPSSPTILLLEAVVMLLDSKLPWVCKIVGHLLQRNTYSLLREIVLTAKESVETYSTGRVPSLECLLTILISHVGQNHCICPIIDPRWSFSSQILTIPFLWALFPYLKEVFMRRGLSEHYIHQMALCVQNHTNVLPDDISADFPGYACLLGNILETASVFFSQPDCSLDMAIDIAAVMTFLLQALPPMKSSNRESKENSSGGEDEMAVGDEIMEKVVSRDLEQQISNAIDPRFLLQLTNALFGGISLINHLCEEGPDDREVAAIGAACAFLHVTFNILPLERIMTVLAYRTELVPLLWKFIKRCHENQKWSSLSEQLAYLSGDMPGWQLPLAVFCPVYKHMLTIVDNEEFYEQEKPLSLSDIRCLIVILRQALWQLLWVNPAMPPNLMKPAPEVTSHRGHPIEFTQQRVSIVTAELLSQLQDWNNRRQFAPPSYFHADAVNEYFISQAVIENTRAYTILKQAPFLVPFTSRVKIFTSQLAAARQRDGSHSVFTRNRFRIRRDHILEDAFNQLSVLSEDDLRGLIRISFVNEFGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETADHLLYPNPGSGMIHEQHLQFFHFLGTVLGKAMFEGILVDIPFATFFLSKLKQKHNYLNDLPSLDPELYRHLIFLKHFEGDLSELELYFVIVNNEYGEQTEEELLPGGKNIRVTNENVITFIHLIANHRLNFQIRQQSTHFLRGFQQLIQRDWIEMFDEHELQLLISGSLDGLDVDDLRSNTNYAGGYHSEHYVIETFWEVLKSFTLENQMKFLKFVTGCSRGPLLGFKYLEPLFCIQRAAGSASEEALDRLPTSATCMNLLKLPPYRSKEQMATKLLYAINADAGFDLS
65
T1ERD2
2.7.7.7
ACT_SITE 64; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MSENKENYVLYQEQMMKTYEQINEKWKALSYKKAIISLKKHPAKISTFEEAKSLSGVGEKLAEKIWEIVESGKLRKLDELSETEEVTSLNTFVNVWGAGPKTAQTWFAQGFRSLKDLEEKAQLTRCQKIGLKYYDELIERMERAEVQKIESVVLTEVNILRPGCELVVCGSYRRGQTTCGDVDILITHPDGSSHVGLFDALIGSLTETGFLTDELIIAHNGPQQKYLGLCKLPESKHRRIDIIVTPHNEFYTALVYFTGSGHFNRSMRHMASKMNMSLNEHGLYTGVTRNNGVKVCSGSSLPITSEESIFKYLGVPFRPPEERDY
121
Q03656
2.7.11.1
ACT_SITE 294; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MGSSINYPGFVTKSAHLADTSTDASISCEEATSSQEAKKNFFQRDYNMMKKAPAPTKSKLSLALQTSKSSSSANGTVQEDTSSKTEDFSTKSIKKKPDSGVESHVSIQSDSGPQSDSDLDSDSSISSCDERNEESLKDYRPGGYHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIGDVEGIVQMVEALDKQKREAKRLQRHVSRSSDITANDSSDEKWAECQTSMPCGSSSNSKSRSIEKDLSKRCFRRPRRHTIITGSQPLPSPISSSNFFEMRAHFCGSSHNSFSSVSGNRNIPSSINNNSINNGIGIKNSNNSFLNSVPHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFDISNISQSSDTNGPYISNTMDSNSNVSTDINSPENLIQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEEVRDHKRH
99
P00697
3.2.1.17
ACT_SITE 53; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"; ACT_SITE 71; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
MKALLVLGFLLLSASVQAKIYERCQFARTLKRNGMSGYYGVSLADWVCLAQHESNYNTQARNYNPGDQSTDYGIFQINSRYWCNDGKTPRAKNACGIPCSALLQDDITQAIQCAKRVVRDPQGIRAWVAWQRHCKNRDLSGYIRNCGV
160
F6Y407
3.2.1.35
ACT_SITE 139; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
MWTSGGPVLAVPWLLAVALAGPRSEEGKPTANPIFTRRPFQVAWNAPTQDCQPRFKVQLDFSVFDVQASPNEGFVDQNLTIFYRERLGLYPFYDTGSVAVHGGVPQNSSIEKHLDRLPDGVKRYIRSSEREGLAVIDWEDWRPVWIRNWQSKDVYRQASRQLVASMHPGWPADQVGKQAQYEFEFAARQFMLQTLRLAKDIRPRQLWGFYLFPDCYNHDYVQNRDSYTGHCPDVEVTRNDQLAWLWAESTAIYPSVYLEEALASSSTNVCKFVRSRVLEALRVAREHHPVYSLPVFVYTRPTYTRKLTGLSEMDLISTIGESAALGAAGIIFWGDTDYTKSRESCQSIKDYLEHKLAPYIANVTTAAQHCSLNLCLGHGRCQRRDSNTSTFLHLNPASFRLRHRANVGEPLLWFEGQLSSGDVAGLRLHFRCQCYQGWHGDKCQHNQSSRGGAGLGQGETSGLLALPALTLLAFTGAQ
166
Q5KQF5
2.7.11.1
ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MPPAGDDESPAATGDGYSKKVLQGRYELGRVLGQGASSKVYRARDARTGAHVAVKAIRKQQQPHHHPSCRSPEAAAAARRCVEVEREVAALRRVRGHPHVVALLDVLATRSTVYLVLELASGGSVLSALDSRGGGHYDEPAARRLFAQLASAVAHAHSLGVFHRDIKPENLLLDERGDLRLTDFGLSAFADADQHLGATDGLAATHCGSPAYVAPEILLKRRYDASKADVWSCGVVLFVLTAGYLPFNDGNLMAMYRKICAAKFRCPKWCSQELRSLIGRMLDPEPDTRIKIGEIFDHPWLQQDGSSSSFGMIQAASSHSKPEVEKWEAELEQAMELNAFDIIGFASGCDLSGLIGPLPDRVRFVLPGGDSKSVLDKVEKLGREEGLVVRRKEEEWCGGVHVEATSGKFTAYVRVNLLPKKILMIEAERVIGSEIPKFWHQLQIGNLLVRK
99
Q8PC63
2.7.6.1
ACT_SITE 198; /evidence="ECO:0000255|HAMAP-Rule:MF_00583"
MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRASAASVTAVIPYFGYSRQDRRMRSSRVPITAKVAAKMICAMEADRVLTVDLHADQIQGFFDVPIDNVYASPLLLADIWRAYGTDNLIVVSPDVGGVVRARAVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSAAARTCPKIRQLSVAELLAETIHRIAFGESVSSLYVD
114
Q9KQF5
5.6.2.1
ACT_SITE 332; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383"
MTRLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEECVDKVPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQTLQGRLEQLIEQVQVAPVPVSLQALPAVSKPAFKRTRRAPKSKARTYKA
221
P47686
1.8.4.12
ACT_SITE 121; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01126"
MSKYQKKSEAELKRTLTKLQFDVTQNAHTEPPYINEYNRNFEKGIYVDITSGEPLFISTDKFKSGCGWPAFSKPIDKNLIANYRDESHGMIRTEVRAKNSDSHLGHVFNDGPSELGGLRYCINSAALKFIPFEEMEKLGYKDYIHLFKNK
40
Q4ZV64
2.2.1.2
ACT_SITE 125; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MTSKLDQLKKFTTVVADTGDFGAIKSLEPEDATTNPSLLLKAASDANNAKMLGEAFDGSKGDIGLACDRFAVAIGQEILKVVPGRVSTEVDARLSFDTNALIERSERLIGLYDAAGIKRDRVLIKLAATWEGIRAAEKLEKDGIQTNLTLLFSFAQAVACAEAGVFLISPFVGRIYDWYKKSTGTDYTGAEDPGVQSVTRIYNYYKANDFKTVVMGASFRNLNQIEQLAGCDRLTISTDLLKKLAEDTGTLERKLTPDKAGEKRSDTVKNLTESQFRWASNEDAMATEKLAEGIRQFARDQEKLEALLSAKKA
52
B9HYG4
3.2.1.21
ACT_SITE 186; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 390; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"
MAKKEEFLKEHEYLNEKEVSRSDFPPDFIFGVATSAYQIEGASNEGGRGPSIWDAFAQSKGNILDGSNGDVAVDHYHRYKEDIEIIAKLGFDAYRFSISWSRIFPDGLGTKVNDEGIAFYNNVINALLEKGIQPYVTLYHWDLPLHLQESMEGWLNKEVVKYFAIYADTCFASFGDRVKHWITLNEPLQTAINGYDSGSFAPGRHDQPSTEPYLASHHQILAHAAAVSIYRNKYKDKQGGQIGLVLDCEWAETGSNKTEDKVAASRRLEFQLGWYLNPLYYGDYPEVMREILGEQLPKFTEEDKELLRNPMDFVGLNHYTSRFITHATESPEESYYYKAQLMERRVEFEGGEPIGEKAASEWLYVCPWGLRKVLNYLAQKYNNPTIYVTENGMDDEDIDAPLHEVLDDNLRVRYFKGYLASVAQAIKDGVQVKGYFAWSLLDNFEWAQGYTKRFGLVYVDYKNGLSRHPKSSAYWFMRFLKGVEGKSGKEE
161
P65240
2.7.6.1
ACT_SITE 196; /evidence="ECO:0000255|HAMAP-Rule:MF_00583"
MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRKARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERRGMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGKTCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVLDTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI
114
P47428
5.4.99.12
ACT_SITE 52; /note="Nucleophile"; /evidence="ECO:0000250"
MARYLGIVSYDGSYFKGWAIQPNLATIQGLLEQSFSLIIGRKIKVIGSGRTDKGVHAINQTFHVDINGEINLNLLIRKINQLIKPHCIVKTLVLVNDSFHARFQVKTKVYEYLINCGNLNPLQFNYVWQLNQQLDLEKLKADATLFLGKKNFLSFSSSIHTDSIRTISKITIQKETNQLVRLTFFGSGFLRSQVRMIVACLVNLNTNKMALETVAKLFEHPKKGSCVVKAPSCGLYLKTVVYEK
217
A0A804IDC2
1.1.1.100
ACT_SITE 231; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1"
MAAAPRIVFTRPSSIPAKFATPRRSLPLQSFSPAVGRGLLARSSVLSSGFRSDGAAYISGVRTHVAAVEQAIIVEAQKVEAPVVIITGASRGIGKAIALTLGKAGCKVLVNYARSSKEAEEVSKEIEAFGGQAITFGGDVSKEADVETMIKTAVDAWGTVDILVNNAGITRDTLLMRMKKTQWQEVIDLNLTGVFLCTQAAAKIMLKKKKGRIINIASVVGLVGNAGQANYSAAKAGVIGFTKTVAKEYASRNINVNAVAPGFIASDMTAKLGEDIEKKILEIIPLGRYGQPEEVAGLVEFLALNPASSYITGQVFTIDGGMVM
2
W5NAC3
3.2.1.35
ACT_SITE 143; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
AALGGGSALLLLLVLLPDAGVRGDSGAPRDEPAAASPALVPRRPFVVVWNMPTARCQRRYGVTLDLDAFDIVENRRGRFLGQNMTIFYRSRLGLYPYISAGGRAVNGGVPQQAPLGRHLGKAGAQMRAALNPDFRGLAVIDWEEWRPLWARNWGRKQKYRQASEQLVRARRPELPEGKVAPLARREFEAGARELMSRTLDLGVQLRPGGLWGFYGFPDCYNYYKGGAGYSGRCHPGAPGLNDRLDWLWRRSTALYPSVYLTRRLGASGATALFVRHRLLEAMRVASKSGSARGARPVLPYARVAYAHTLHYLSQSELEQTLGESAALGAAGVVLWGDLSFAGSKVRCRLTFIFIDYCLSLWCVVETXAARCSELECSGNGRCARRDPHSGATLPSASLGSPGEVAPPGLRDSAFSCVCYQGWAGPQCQD
166
A0A2K2CLP7
3.1.1.11
ACT_SITE 238; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGCNMALPLLLSMAVLASQRHTLTAAAPAAAAGAFGSWVTDNQKDFAINQALYAKKAVGNTGDTIDERLAKAEANKTTYIVDPKGGGDYTNITAAIADIPEGNTGRVILDLKPGVYREKVFLNLSKPYVTFKADPLNPAIIAWNDTAATPGKDGKPVGTVGSTTCAIESDYFVAYGVVFKNDAPLAKPGAKGGQAVALRVFGTKAAFYNCTIDGGQDTLYDHKGLHYFKDCIIRGSVDFIFGFGRSFYEGCDIISIVKEVAVLTAQQRTKTIEGAIESGFSFKNCSIRGEGGGQIFLGRAWGDSSRVVYAYTEMSKEVVPVGWDGWNIKQPESSGIYYGEFKCSGPGSDARKRIGWALDLTESQAKPFIGTHYVFGDSWIRPPPTGSSPPSSKKPSSSAAASPADSPAESPSSSFEASSPESSEAPASSKASSPAKSSESYSKDKKKKEL
125
Q8T487
3.4.19.12
ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 178; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
MDTENPGAATVEELTTKEATAANNWCLIESDPGVFTEMISGFGCTGAEVEEIWSIKADAFRHLEPIHGLIFLFKWLDDKPAGRVVTDRSDIFFARQVIPNACATQALLCLLLNLEHEDIDLGQTLTDLRNLCQDLDPECRGHRLANEEKIRKVHNSFARPELFVVEESTDFIEDDCYHFVGFMPIKGKLFELDGMHEGPIELADIDQQQNWLDVVRPIIAARMERYSVGEIHFNLMALVSDRQRCYERKIQMLVNLPSQLSHADRQAEIANLRSHVRHEKEKKRRYRKENIRRRHNYLPFIVELLKQLGETGQLMAICDKAKDRSYLCKPSKDTRDQQPQ
175
Q9M3D7
2.7.11.1
ACT_SITE 474; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDCRLHLVLFFSCVCLICLSGQQETGFVYNGFHQEDLFIDGIAMILPGGLLQLTNASQLKIGHAFFKQPFGFDPSSSLSFYTHFVCALVPPKFGAEVGHGMAFVVSPSMNFSHAFPTQYLGVFNSSTNVTSSSHLLAIELDTVETVDFHDLEKAHVGIDVNNPISIESALPSYFSDALGKNISINLVSGEPVQVWIDYDGSLLNVTLAPIEIQKPNRPLISRDINLSEIFQDKMYIGFSGSNGRLTSNQYILGWSFSKSKEFMQSLDLSKLPQAPIPRNEQAPVPREEKKKLHPLLIGLVILLVIPVLMVLGGVYWYRRKKYAEVKESWEKEYGPHRYSYKSLYKATNGFVKDALVGKGGFGKVYKGTLPGGRHIAVKRLSHDAEQGMKQFVAEVVTMGNIQHRNLVPLLGYCRRKGELLLVSEYMSNGSLDQYLFYNQNPSPSWLQRISILKDIASALNYLHSGANPAVLHRDIKASNVMLDSEYNGRLGDFGMAKFQDPQGNLSATAAVGTIGYMAPELIRTGTSKETDVYAFGIFLLEVTCGRRPFEPELPVQKKYLVKWVCECWKQASLLETRDPKLGREFLSEEVEMVLKLGLLCTNDVPESRPDMGQVMQYLSQKQPLPDFSADSPGIGGFMPVSVEPSSTIGIPDSSMHVTHSILEGYGR
99
H3H7X5
2.3.2.26
ACT_SITE 242; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MQAVVGFLAVLAVIALLFCCLSLLARRAYIRRQRSLELHAPLLNSDDRRLDAALRDAEEGFNVCAVCSFENFRRVKFCTVCGQALADDEQQNGDKKAPRLSFLPLFKRESRVQLVTATPTHQTTRRRLRAQRRKEWTRKVDVEGRTFWFRDGRWTDTRFTGFVVKFLSTCDLHHHRSLKWFWELVREMPNEYRRRLLQFSTGSSRVPLGGFSALTSYDGRLCPFTLKAVSLIGDGFIHSHACFNRLDLPLHVVRDELKAVLYAVLETEVYGFTTD
65
P83778
1.1.1.37
ACT_SITE 184; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P00346"
MVKVAILGAAGGIGQPLSLLTKLNPNVDELALFDVVNVPGVGADLSHINSDSKTQSYLPKDKEDKTALAAALKGSDLVIIPAGVPRKPGMTRDDLFNINASIVQGLAEGIAANSPKAFVLVISNPVNSTVPIVAETLQAKGVYDPARLFGVTTLDIVRANTFISQLFLDQTKPSDFNINVVGGHSGETIVPLYSLGNSKQYYDILSEEQKKELIKRVQFGGDEVVQAKNGAGSATLSMAYAGYRLAESILAAVNGKTDIVECTFLNLDSSIKGASEARKLVKDLDFFSLPVQLGKNGITEVKYDILNQISDDEKKLLEVAIEQLQKNIEKGVSFAKK
5
A0A059D160
4.1.1.50
ACT_SITE 66; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 80; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 251; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 264; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MAVSGFEGFEKRIELRFFGDDPLFTGSMGLRNLDFESLEEILHAVQCTVVSAVANRHFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSVRPLVHLASDRLGLTVRMCRYTRGSFIFPKAQPFPHTSFEEEVIFLEENLPSRLCFRKACVMPSNVSSHSWHVFTACDGDDDDDSSHHHELGEDQNDALYTIEMCMTELDQASARKFFRRGAGDDEKYSGDSAGREMTGLTGIGDINPRALICDFGFDPCGYSMNGIDGERYSTIHVTPEEGFSYASYECVGSIYDDPHEISRVLKKVAQVFRPGTMSVATTCASHDLWRRVAKALELVGLKCRSCSADEFPAAGTVVFQTFTTTRRK
196
A0A251TJC1
1.11.1.7
ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKVYTLMCLLLATLATMTQGQTRVGFYSTTCPRVETIVRNAVQTAVRADPTLAAGVLRIFFHDCFVNGCDGSVLLDGPSSEKTAPPNVPLRGFEVIDAAKSQLETACPGVVSCADIAALAARDAVVLAGGTSWQVPLGRRDGLVSQASDTVNLPGFNDPISVQIRKFADKNLNIQDLVTLVGGHTIGTGACVVFSYRLYNFNNTNQPDPDINPAFLPQLRALCPNGGDGSRRVALDTGSVTRFDNSFYANLRNGRGVLESDAKLWSDPTTRPIVQRFLGLSGLLGLTFNVEFGRSMVKMGNIELKTGSQGEIRRVCRATN
14
H3GMT2
3.1.3.1
ACT_SITE 95; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MTNPARVVALCAAALALAGAATHYEYKTVDVDYNFDENENDPRSVIMMIPDGTGPNVFTLARTVLDPTLKTRLHIDPHLMGTIQTHSSTSYITDSAAAATAYATGYKTYDNAIAVDTYEQPLGTVLEAAKARGMVTGMIVTCRVTHATPASFAAHVVDRDSEDDIAAQYVANKNLDFLLGGGKKHFNESMFEDLQSNGYTLANNYQDLLDYQTANADTGALRLFGLFKDSHMTYEVDRLRELVDDNSTAREPSLPEMVDIVLSLLRKNEQAKKHGYFIMIEGSRVDHAGHSNDPGTMAKEAIAFDETVAVVLDHVEQMPNTGLLSAADHGTGGITLGRGPAYPYAWYPTELQLQNMSTEAMQAQLEDVLEGSDCATGGNETCKASLLTSAKTLLSNYTNVTTVNDDEVVELVSLIATAVDETRDLEDVMIELGHVISLRAAIDWTTIGHVGTDVNLYCKGPLIFERMCKGVHENTYLNKLMTMFLGLEHQQELETMKHRNVTVLEDPLNF
141
Q8BN21
2.7.11.1
ACT_SITE 166; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAPRRKEKYKLPVPLPEGKILDDMEGNRWALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLDQNGGFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDFTNPDRVYLADYGLSYRYCPNGNHKQYQEDPRKGHNGTIEFTSLDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVLKWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKILNPDGVPLGPLEFSTKVQSVHVRTPAQQKVDSPKATRKPANEFPAKFPKKVHRETRARQREEQEDSQPTMLQSRPAAPENSRTRKIHEYSDIFSEMQSLQQTPSYMSFQGSYCKPYLDCTRRDPIRKPRSLPRYRHTPTGNLGVTDLESSPRFWPAIFQLTLSEETKADVYYYGITIFCLLIFVFLALYFL
99
A0A804JT79
3.5.1.2
ACT_SITE 79; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 203; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 205; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"
MTTVGVLALQGSFNEHMAALRRIGVKGVEIRKAEQLQAVDALIIPGGESTTMAKLAHYHNLFPALREFVSTGKPVWGTCAGLIFLANKAIGQKSGGQELIGGLDCIVNRNFFGSQLQSFETELSVPKLAEEEGGPNGFRGVFIRAPAILEVGPDVEILADCPVPLETKKSIMSVDNGQEEEIVSRERVIVAVRQGNLLGTAFHPELTTDLRWHSLFLKMKKDSSDRCLQRVPTSGTDLEDSLGKRPFDLPIYE
181
Q56JZ2
3.1.1.4
ACT_SITE 67; /evidence="ECO:0000250"; ACT_SITE 111; /evidence="ECO:0000250"
MKTLLLLAVIMAIGLLQVHGDLLNFRKMIKLTTGKEPATRYSFYGCYCGMSGRGTPKDATDWCCRAHDCCYKNLESRGCRTKFLKYNVTYQEDQIVCEDADDCKSQVCQCDKIAANCFAANLKTYNKKLRFYNKFRCRGAAPAC
130
A0A3B6NRR3
3.2.1.14
ACT_SITE 132; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
MARVLALGAAAAFLLLAVASTMAAAQNCGCAATECCSRWGFCGTTGEYCGTGCRSGPCTVPVTNNVSVPAIVTPAFFGALVAQAADDCAAKGFYTRDAFLTALGGYPAFGRTGSDDDSKREIAAFFAHVNHETIKFCYIDEINGPSKNYCDPTNAEWTCAAGKGYYGRGPLQISWNYNYGAAGQSLGFDGLNDPDAVARSPVLAFQAALWYWMNSVHDIIVSGQGFGATIRAINGALECNGKNPSAVNDRVAFYKQFCQQFGVDPGTSLTC
158
Q54DY0
2.7.11.1
ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSNQRVLYWPETYNNIKELGRGVSGVVYKASHKKTGQIVAIKLVDMKQSKISTEQIQGEIRALLTLNPENERTHINIIKLIQCFIHKTTAIFILEYVDGGTLEDFMYSFERGMPLSLISHCLYQSVNAIEYMNSKKCSHRDIKPANILMLRNRKPKLKQQSEQQQQEDGGYIRYSGQFQLEPSSQENNNYQFDPDELPILKVTDYGYASISGNDSAEIHSTLAGSPLYMAPEIIHIILSPFLEPGTGKLSADSSEGYNPLLVDVWAIGAVAFRLITGDDLISVIFPNLNQTTVLAALVNLAKMIDNGDFQKGLDSIPNEIRKYGLVDPDIELGISFITSLLQLDPKKRLPLKETLNHPFLAKGKLSFTQTLNQHYKDNKDVLGSIVPSDISNFLNQNQQQQQQQQKSFSTSSLPQVNHNNDTNNNNNNNNNNNNNNNNNNNNNNNNNNNNEKDKDNQSNNSSSSSSSSSPPSPTISKSSPSSLSSSLSPSSSTDDLPKAMKWSSSVKPPKKSNFAPTFLSHQRSDKITLFPKLLPPPTKDAPPLETMNWRSPPVEVGDSITWTTLTQDAIFQVQFSVLTSFLKVISASNSYQFRIITSLTKVPLEIAVSNHKDTILYMYNIVKSVIAPQLISLSNAFDENSIRSVLAAILYQIGTETEQAEIANCWTLV
99
A0A022QK95
2.3.2.26
ACT_SITE 808; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MRKDQNALPSSSNSSSSNSPSSTRPLPSWPRSSPAGDTHLQFFVRILSYHSLVVQADSSDTVRSIHEKIESITGISIFEQRLIYRGRQLQLEQTLAECKVQNDASLNLVGRMRSTGYPEAWHLINDVVSMIFRMYKTNPPSNRQNPKTLRTKLTNFVSDSLKDPLRDSVKSREKLSGYLQIFNSSSATGALVMLYMSSCKTNKEEAEEAIKSFITSIKNSWKHFCLDTVLIVLEFCRLLNKTAGIDDPLYCFCRRTLGEMAKEESIGIANKDIEKKKCLIGIHDIFPFVNELASKLSRDLMSSTEPTFFPRLSPKDVTDFSTFIEAMKIQIERRVGFGGPIRVPLTEELPLDYADNVIILHGIFTHLLSKLENVLVKIEEHVEWGQKKKEPDTHLLQWYEYLRVLKELNSISKLYYGCEKVFWETMKRRKDVLCYLVVMCAKRKDDNNWILDCKELTNFEVRRCLAMFILPEVKDEYNDLHEMLIDRAHLLEESYEYIVHADLDSLRAGLFMEFKNEEATGPGVLREWFFLVCQAIFNPQNALFVACPNDRRRFYPNPASKVDPLHLKYFSFSGKVIALALMHKVQVGIVLDRVFFLQLAGQTITLEDIKDADPYLYNSCKQILEMDPTTIDQDALGLTFIDEKEELGARKVIELCPDGKNVIVNSKNRRRYIDSLIQHRFVTSISEQVAHFTEGFADIMSSNEIKRSFFRCLNHEDLDCMLHGSENGISVEDWRAHTDYHGFVKTDLQISWFWEIVGNMTKEQKKILLFFWTSIKYLPVEGFSGLASRLYIYKTSEPIDRLPSSHTCFYRLCFPAYTTINDMQERLRIITQEHVGCSFGTW
65
M5XGR4
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASLLFISLPLLLIIMAVVLVTPAISVPLKIGFYQTACPSAESMVRNTVTKALAADPAIAAALIRLHFHDCFVRGCDASILLDSKPGMPAEKESTMNKGVQGFEVIDEAKAAIEAQCPNTVSCADIIAFAARDSVFSAGGLRYAVAGGRRDGLASLIYEAAKNLPGAFFNSTELRGNFARKGLSMEEMVTLSGAHSIGESHCSAFSKRLYSFSARFPQDPSMDGAYAETLKSKCPRPRNLTDSVDPVVAFDLSTPALLDNNYYKNLVSHRGLLASDQELWSSGLTRKMVKYNRNHPGAWASKFAAAMVKMGSIDVMVGRNGEIRNNCRAVN
14
K7UUE2
3.1.1.11
ACT_SITE 409; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MALHSAAAAAALSALLMLSFSGLTLSDTTPSTPVSPSAACNATTDPTFCRSVLPPRGKGDLYKYGRFSVAESLAGARMFAALVDRYLARHRHLSSSAIGALRDCQLMADLNVDFLTAAGATIKTTDTLLDPQADDVHTLLSAILTNQQTCFDGLQAASGSWSDRGGLDAPIANGTKLYSLSLSLFTRAWVPTAKPAHSHKGGSNDPHHGHGHGHGDKNKKHPAASAARRGLFDVTDDEMVRRMAIEGPEATVEVNTVVTVDQSGAGNFTTIGDAVAAAPRNLNGSTGYYVVYVLAGVYEENVVVPKHSKYIMLVGDGIGQTVVTGNRSVVDGWTTFQSATFAVVGQGFVAVNMTFRNTAGPAKHQAVAFRSGADLSAYYGCSFEAYQDTLYTHSLRQFYRGCDIYGTVDYVFGNAAVVFQGCTFYSRLPMQGQCNTVTAQGRSDPNQNTGTSIQGCSLVAAPELAANTAFTTLSYLGRPWKNFSRTVVMESYVGALVDPSGWMPWSGDFALSTLYYAEYNNTGPGADTSRRVAWPGFHVLGDGTDAGNFTVSSMVLGENWLPQTGVPFTSGLIP
125
K3ZIC1
3.1.3.3
ACT_SITE 266; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 268; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MRCTEARRKELAAPIGGEEKGDTESPDRIPASVNEVATWRRECGGRQEKSNPRPVGGAGGRWRLVGTGRIPKSDPGHAVAAPPPSPAARRRRSLVASRQDEWSGRWLHVGPRDGRAHMSLGDSGGVEEGGRWVDSNVCHHQGTNTHRLVSAIPTGRSGGAARSSLPLESSGPGAYGMAGLIGARAGPGSLLPVRWSSATARPPPASKVAVRFASPLFRSAKVCKSRGLVAAALEVSKDGGTAVLANRQPSKGVIETLQNADAVCFDVDSTVIQDEGIDELADFCGAGKAVAEWTAKAMTGTVPFEEALAARLSLIKPSLSQIEECLVKRPPRISPGMADLVKKLKANNTDVFLVSGGFRQMIKPVASELGIPAENIIANQVLFGTSGEYAGFDPTEPTSRSGGKAQAVQQIKQNYGYKTVIMIGDGATDLEARQPGGADLFICYAGVQLREPVAAEADWVVSDFEELITKLP
147
A0A2R6W7E6
1.1.1.37
ACT_SITE 210; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MASARGSIVRSLRLVGQHVQKQQSREMSSSSGPQRKVAVLGAAGGIGQPLGLLMKLNPLVTHLSLYDIAGTPGVAADISHCNTPAEVSGYAGDADLGKALEGADIVIIPAGVPRKPGMTRDDLFKINAGIVKSLCAAISQHCPEALVAMISNPVNSTVPIAAEVFKKAGTYDPRKLFGVTTLDVVRARTFYAAKKGLNVRDVDVPVVGGHAGITILPLFSQATPKKSLEGEELDALTKRTQDGGTEVVQAKAGKGSATLSMAYAGALFAEACLKGLNGQKGVIECTYVQSSIIPELPFFSSKVRLGPNGVEEIMGLGQITEYESKALEAMKSELASSIQKGVDFVHQS
5
A8XHZ7
3.4.19.12
ACT_SITE 83; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 158; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
MADAGNWCLIESDPGVFTEMLRGFAVDGLQVEELWSLDDDKALMKPVYGLIFLFKWRQGDEGAGVPSTKENIFFAQQVIQNACATQALINLLMNVSDPAVKLGPILTQYKEFAIDMDPATRGLCLSNCEDIRTVHNSFSRQTLFELDVKGGDSEDNYHFVTYVPIGDKVFELDGLREAPLEVSDLPDGKDWVEAVRPIIQERMAKYSQGEITFNLMALVPNRQQKYQEMLDALTQANENGELDEQITDITINIQEEERKMTTYRKENARRRHNYTPFVIQLLKILAKEGKLVGLINDAYQKAEARAKKPALNTDKTVLKLKDESMD
175
P38615
2.7.11.1
ACT_SITE 164; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNIQSNNSPNLSNNIVSKQVYYAHPPPTIDPNDPVQISFPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKFPQIKPIPLSRVFKKEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDELKLDDGKINQITTDLKLLEFDENVELGHLSPDELSSVKKKLYPKSK
99
Q7S5B5
2.3.1.48
ACT_SITE 589; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MASLKRKRHRGGTDSGTSSSEAAAAAGGVGAATAAAPLASGSPVTRARRATRQTSTAPLPVLPDPEPPRRRRRRDSTGTGTGTGTGLATDRQSPTSPPLLPPPGPPPPPPPPAHRDKENIPMQSNSHHGHAPIIKTRLTRHTGFDFDPPSSVPTPPSSSSNSNSNSNSSSHPPRPHAASSHSSSNSSHSGPRAITPARSITIKTSTSTAHQSPLAHPHQAPTASPLRAPAPNPTTKILPGPLAGGQARHDSTTAHGHGRSATGPVVLPHHSIVGQNKTISMAPSVPPPTQHQQQQQQQQQQHTHRSPIARPGPSGGKSDRPERAPGERPDRNIDKVVLGDICFRAWYPSYYGKEVLGEGPPSVGTTIANGTNPSNQAAHGHQPHHQPPMLDRLYVCPCCFKYSKELVAWRRHVCLCEARGHIPGTKVYVHPKGRRTVLVPTGPAPKPGRGKRGSIGQKMVEEVIQDEGEWTIWKVDGAEDMLFCQNLSLFAKLFLDNKSVFFDVSGFHYFLLVFTPPDPPTDPDSDVTEVVKPRGQVVGFFSKEKMSWDNNNLACILIFPPWQRKGLGALLMGVSYEISRREGIIGGPEKPISELGKKGYKRFWAGEIARWLLSLEPTGTTPGEETVVDIEDCSKATWIAPDDCLAVLREMDVAEDAGKGPPKPKIHEPSEEEVGTTPSEAPAPAPAAAAAVVVEDVPRVRITLEAVHNWVTRNRISLERTCDPAGFIDDFVMEEPSSEEEG
61
A0A1L8ELE2
3.1.3.48
ACT_SITE 290; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 292; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"
MIDLLISQSLSVSSGSSEDLKFDLSDSLPESPDDIADKSKKVSSRESFPHSGNSKESQQFTPEGNYSRQYPHIVSPPSVPGMAAYGQTQYSAGIQQTAAYSTYPPPGQSYGIPSYSIKTEDSLSHSPGQSGFLTYGSSFSTSSPGQAPYTYQVHGPSGIYQGANGLANAGAFGSVHQEYSSYPGFSQGQYPQYYSSSYNSPYVPTNSISPTALSTAAYSIHESSQHISNQSTESLSGEYNAHNGPSTPIKDAENDRQHRGSDAKLRGRSKRSNDPSPAVDNEIERVFVWDLDETIIIFHSLLTGTFATRYGKDTTTAVRVGLMMEEMIFNLADTHLFFNDLEECDQIHIDDVSSDDNGQDLSTYNFSSDGFHSSAAGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYSTYKNNVGGLIGAPKRETWLQLRAEMEAVTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPAIAKVLLYGLGTVFPIENIYSATKTGKECCFERIMQRFGRKAVYVVIGDGVEEEQAAKKHNMPFWRISCHADLEALRHALDLEYL
149
P0CQ34
6.3.4.4
ACT_SITE 18; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 46; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"
MAPSPEGVTVVLGAQWGDEGKGKLVDILAAEADICARCAGGNNAGHTIVVRNDKGEKTSYAFNLLPSGLINPECTAFIGSGVVVHVPSLFNELDTLERKGLKVAGRLFVSDRAHLVMGFHQIVDGLKEVELGGSSIGTTRKGIGPAYSSKASRSGLRVHHLFDPTFPAKFRKLVEGRFKRYGHFEFDTEGEIEMYLAFAERLRPFIVDGPTFMHNAVNSGKRVLVEGANALMLDLDYGTYPFVTSSSTSIGGVVSGLGISPFAIKRVVGVIKAYTTRVGGGPFPTEDLATVGETLQEVGAEYGTVTGRRRRCGWLDLVVMKYSTMINGYTSLNLTKLDVLDGFDEIKVATGYKIDGVEVEGFPADLDRLAKVEVQYATLPGWKTDISNCKTYEEFPENAKAYIKFIEDYLGVKVQYVGVGPGRDQNVIIF
253
A0A8M9QKN6
2.7.10.1
ACT_SITE 781; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MFFMLLFLIGILLGQVQGWSEPRIRLSSGALAGTDVILESGSPLQLVCEGDGPVTFLPRLAKHKRYISKEVGKIRSFRVEKTTVDFTGTYKCVYMNGNDSNLSSSVHVFVRDSRVLFVSPSTSLRYVRKEGEDLLLPCLLTDPEATDFTFRMDNGSAAPYGMNITYDPRKGVLIRNVHPGFNADYICCARIGGAEKVSKIFSINIIQRLRFPPYVYLKRNEYVKLVGERLQISCTTNNPNFYYNVTWTHSSRMLPKAEEKSTMEGDRLAIESILTIPSVQLSHTGNITCTGQNEAGANSSTTHLLVVEEPYIRLSPKLSSKLTHRGLSIEVSEGDDVDLGVLIEAYPPLTSHKWETPTSHNASLPENRFFNHNDRYEALLLLKRLNFEEIGQYTLNVKNSMKSASITFDIKMYTKPVARVKWENVTTLSCRSYGYPAPSILWYQCTGIRTTCPENTTDLQPIQTQTVEFQKESFGAVGVESVLTVGPNRRMTVVCVAFNLVGQGSDTFSMEVSDQIFTSAMCGSTVAMVVLGLLLIFMIYKYKQKPRYEIRWKIIEATNGNNYTFIDPTQLPYNEKWEFPRDKLKLGKTLGAGAFGKVVEATAYGLGKEDNITRVAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLGACTHGGPVLVITEYCCHGDLLNFLRSKAENFLNFVMTIPNFPEPMTDYKNVSTERMFVRSDSGISSTCSDHYLDMRPVTSRPTNSALDSSSECQEDSWPLDMDDLLRFSSQVAQGLDFLAAKNCIHRDVAARNVLLTNSRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFECVYTVQSDVWSYGIMLWEIFSLGKSPYPNILVDSKFYKMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTFSKISQMIQRMLGETSEQQDTQEYKNIPTEAEAEQQLESCDPVKHEDESFETSCDQEEEDQPLMKPNNYQFC
97
A0A9J7M9B4
2.7.11.1
ACT_SITE 325; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 342; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"
MAATMDDSTPGPVPGQFDDVDEPSLNSYPAETSSPVMETFPARVSELSVTEDSQQPDVWDESDEDYADWDWEDHSGDFTKRYNAAQHNSAQMNPNKPKPGKVSFQPTDKTMTKFASKITVEKYFGPKLRGAAASALLEGVRKSDSDRYRVKDRQDRATVEQVLDPRTRMILFKMLNRGIIQQINGCISTGKEANVYHATCKDGTDKAIKVYKTSILVFKDRDRYVTGEFRFRHGYCKHNPRKMVKTWAEKEMRNLTRMYQAEIPCPEPVILRSHVLVMEFIGKDGWPAPLLKDVQLSVSKARELYLQVIQLMRTMFHDCRLVHADLSEFNMLYLDGQVYIIDVSQSVEHDHPHALEFLRKDCTNINDYFVKNGVAVMTVKELFNFVTDININTDNIDEYVDKAMEVASSRSIQEVKEQDKVDEEVFKKVFIPRTLEEVPDFERDINSKQHGSELEIHYQAVTGLKDDLTGPLTKPSLLEEEEAQNDEEEAREDSDNSSGSESDSEKDRSEHTQYTRQRGESADSRRARKKLVKEENREKRKQKMPKHIKKRKEKIAKQKHGRN
99
P37146
1.17.4.1
ACT_SITE 105; /evidence="ECO:0000255|PROSITE-ProRule:PRU10014"
MKLSRISAINWNKISDDKDLEVWNRLTSNFWLPEKVPLSNDIPAWQTLTVVEQQLTMRVFTGLTLLDTLQNVIGAPSLMPDALTPHEEAVLSNISFMEAVHARSYSSIFSTLCQTKDVDAAYAWSEENAPLQRKAQIIQQHYRGDDPLKKKIASVFLESFLFYSGFWLPMYFSSRGKLTNTADLIRLIIRDEAVHGYYIGYKYQKNMEKISLGQREELKSFAFDLLLELYDNELQYTDELYAETPWADDVKAFLCYNANKALMNLGYEPLFPAEMAEVNPAILAALSPNADENHDFFSGSGSSYVMGKAVETEDEDWNF
21
Q8EZU7
3.4.21.89
ACT_SITE 49; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 101; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MSYVNMKSIVMQKSTRKYLRVILPIFLSLFTILLIRIFLFQIYFISGYSMAPSYKEGDLILVTKFGFPTRIGKWEISFVESKVNRFDVLVLDGFEEELSLKRVVGLPGDYFRFENDRILINDSPLQETFLKPGFKTIAPSLSMIPMTAAKGNVPIGDTGRIPPGYFLMLGDNRENSTDSRNYGLVPFQKLRGRVWIFL
178
E3KQE3
2.3.1.48
ACT_SITE 391; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MLRTNQAHSNNTHPTDQPPSEKRRRTGKDTTSHGPTLEVALVDVDLVVFGRYEINAWFPSPYVIDQIEYRQATLNNHPNPPPPQPNQPTAPHSKRQSNGPFQGKKTKKGNNKHPTQPFQEAPHNTLPTSPSNSSPPHQQQENINHHQDRKRDRSPSPDSLSSLESTSSVPSNHSDLHPTHPLLPVPPKHLYPTPQSHPSSLTSDTGPIKPTPTSNHLPQPDPPPALKLYVCDGCLRYLFSSEAYLQHKMRCNVTHPPGRKVYQSGNLIIREVDGSRAKLYCQCLCLFGKLFIDHKYIFFDVEGFNFYVLTSAESDQRTGGIRETIMGFFSKEKVSYDGYNLACIVTLPPYQKKGYGTLLIEFSYELDRFEADKEIGSFRDDSRKLILGTPERPLSTLGARGYLSFWTAVLVRFFRTLFTPPPPRLGAELDKQLGTNKKIPRTAKMMATPEKTIEISLEEISRSTRLRSDDVAFALISSGLAKPKHSTAISSSSDSEPSHEPDRFPESFLITPELVELVARRVNVKSAILDPRHVLLNQADPHHLHDLDPHLPLHNGLLPLDHPPHPSSSPPPHPSDSDSALHPSTPVCPPLPIFLRSSKNSAFSNCAPSRKSSAS
61
A0A804NTN9
3.4.21.92
ACT_SITE 251; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 276; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MCVPTSFLFFFIVRMCMAYLPTHCYLRPVLPQPRPIRLTLIPGIPLPSLPSQRPPPPATACLRSPAPPFRYSQRDAAASMTPSSALALALQAAASPLPASTPRSSPRSSSLSLGRGTAGNGPRRLAAAAPPRAFFSSSPYQPPQPEGFSPHREYGLVPMVIETTSRGERAYDIFSRLLKERIVCINGPIADDTASLVVAQLLFLESENPLKPVHLYINSPGGVVTAGLAIYDTMQYIRCPVTTLCIGQAASMGSLLLAAGAPGERRALPNARVMIHQPSGGAQGQATDIAIQAKEILKLRDRLNKIYQKHTRQPIDKIEQCMERDLFMDPDEARDWGLIDEVIENRPASLMPDGIVGGLDVPSLGGGGGGGGRGSDVEEPSAV
179
B1L3K8
6.5.1.1
ACT_SITE 236; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00407"
MLLKELAELAMRIASTSSRRDKVSLVSDLIRRSDPEEAYKALLILTGRIFPPSDPRELNVSWATLWKVVSSLSGAEPTGVDAGELVKSIVERRGKRQTALLEEPLTVEEVYKILEAISEAEGPGSKGKREALLTIPFSRADPSEAWLLANAIVGETRLGLNEGLLIESIAQAYGLRKEDVERAVMVLGDPYEIVRRGGKLEFEPVLFRPLKPMLAQSSDSLRSAIEELGRCALEYKLDGVRVQVHKRGDEVRFFSRRMSDITKSLPDVSDQVRYGVRAGEAILEGELIAERDGRPLPFQILIRRFKRRQLDPRLIEEIPLKLYIFDLILLDGSSYLRKPYFERREKLEGLIEDPVSLVRSLITSDPDEGMDFMEEALREGHEGVIAKKLNSPYIPGVRGRYWLKVKETNSLDLVIVAAERGYGRRHRWYSDYYLAARDPESGEFLIVGKTFKGLTDEEFEWITQKLEELSIGKEGKLIRVRPRIVVEVSFNEIQRSPKYKSGFALRFARITRIRDDKSPEEADTIERVREIYEKQIRKFQL
254
Q9HD43
3.1.3.48
ACT_SITE 1020; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044"
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
149
A7LXU0
3.2.1.55
ACT_SITE 38; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:27466444"; ACT_SITE 198; /note="Proton donor"; /evidence="ECO:0000305|PubMed:27466444"
MMKNSCRLLLILIGLWMANVSLAQKTFRNPIITGMNPDPSICRVGDDFYLVTSTFEYFPGLPVYHSKDLVHWKLIGHALSRPENNPLMGCNASTGGQYAPTLRYHDGTFYVIGTNYGGKGSQGVFYVTAKNPAGPWSDPVWVGNWYVDPSIEFIDGKMYFLSPDNQGSFLLGVMDPETGTFVEALRKVASGLGGSSPEGPHFYKIGDYYYIMSAEGGTGYEHREVIQRSKSPWGPYEPSPVNPVLSNMNCPDHPFQAIGHADLVQLKDGSWWAVCLGIRPVNGKYQHLGRETFLAPVTWDADGWPKVGKDGVVQETYLFPNLPSHVWMEQPVRDDFDQETLGLDWTFIRNPAHSFWSLTEKPGSLRLKGTAINFTTNDSPSFIGRRQAAFNLTASAKVNFIPKVENEEAGLVVRADDKNHYDLLITERNGQRVAMIRKTLKDKVVDTTCKELPATGEVILSITATETTYTFEIKAAHVSAILGTASTRDVSNEVVGGFTGVFIGMYASGNGQANTNPADFDWFDFRCLD
171
A0A804MIP8
1.11.1.7
ACT_SITE 114; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSLLGPPARGAICLLVVSSSIVVLSTAGGLGSDATSRSAAAYLSVDDDYGEEDESGDSSFSFPDPETSSASTGLVFGFYDDKCPDAEEMVSSMVRKLYHADPNVAAALVRLFFHDCFIHGCDASVLLDRVGGQRSERDAGPNQSLRGLGAVEAIKRGVEKACPGTVSCADILALAARDSLVLVGGPTYPVLTGRRDSAQSFYYDADGGGIPPPNATYAMTLDAFARRGQFTERETVALLGAHSIGKVRCRFIADRIYNFAGTGAPDDSIDPDMVGEMRAACGGGDGAAPMEMGYYRQGREVGFGAHYYAELLEGRGILRADQQLTAGSTVRWVRVYASGARGEELFRDDFAHAMVKLSALAPLTGSAGQDLGLEFEGKGGLMPF
14
A0A2K1JM96
3.4.19.12
ACT_SITE 22; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 136; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 151; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
MATDTNNGSGNLYHERQHFQFCLLHCLNNLLQGENSFSRNELNSIADGLPTDLEGRNMPNPLSLIFKPHRNAITGNYDANVLISALNSRNKEVVWFDRRNGAETLLTEIADYGDRLLGIIVNISTRKWLGMWQARHWVAIRKLQGVWYNLDSDHTTPVCFVNGEDGLRDYFNSVISSDGVVLFVLNGVSTLSNGSC
175
Q8YA61
3.2.1.21
ACT_SITE 363; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
MNNNFLWGGATASYQCEGAWDVDGKAESMWDYYLHEAGLENGDVASDHYHRYEEDIRMMKEGGQNSYRFSLSWPRIIKNRQGDINLKGIEFYQNLLDTCKKYDIEPFVTLYHWDLPQYWEETGGWLDHDVCAAFEHYAKVCYDHFGDKITNWTTFNEPKWFVANGYKIGNYPPGYQDTQKTMIAAYNVMYASALGVKAFKEGGYPGQIGIVHSYTPVNGIDESIETKIAMRYADNYCNNWILDTAALGEFPVDLIAELAKSHDISFMKTDELQTIKQNTVDFIGLNYYSRTLVKPYTGGETQLQFNHSGKKGESKVLIKNWFEQVKDPANETTEWDTEIYPKGLQDGLIEAYERYQLPLYVTENGIGVREDVSVPQVDDAYRIAFMNDHINAIFNAIDAGCDVRGYYAWSPFDLYSWKNGVEKRYGLVAVDFENNQIRKPKASYYWFKEMIESQGKLIKRREF
161
W5N3Z9
3.1.3.48
ACT_SITE 277; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
ASPPAHMDQPTPPPPTTRRQARLQERRGSNVSLVLDVSSLGAVEPLCSISTPREITLHFLRNTRRPLTAAELQEAAANTQELSQEYLKIPPNFVDQAELDIPGHALKDRYKTILPNPQTRVCLWKPGAEGDGETYINANYIRGYDGTEKSYIATQGPMVNTVCDFWEMVWQERSAVIVMITKLKEKKEKCVLYWPEKTGTYGRFEVTVDEVKECDSYTLRVLTVRVQSESRQVKHYWYSSWLDHQTPACVQSVLKLVKAVQESQRALCCPGPIIVHCSAGIGRTGCFIATSIGCQQLEKTGEVDILGIVCQLRIDRGGMIQTSEQYHFLYLTLALHSRQLTGT
149
A7SPT7
3.4.19.9
ACT_SITE 127; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 239; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 239; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MAVFNFRIVFITFLLAKVHSLSVEEVKTHRPIIGILAEKVYGSSSKSYIAASYVKYIESAGGRVVPIFPDMSEDKLEKLFYSINGVLFPGGGVDLSKSGYAKNGKFLYNMALKAYDKGDIFPVWGSCLGFELLTVITSDDKVALSRVDAENLPLPLNFSEGFRGSRLFADAPDGLIKAVQTSNITLNNHHYALAPGDFGKNDALSSFYKVLSTNVDRKGKEFISTVEGIKYPVYGVQWHPEKNQFEWSRREDIPHSKEAIQIGQYMANFLVNQARMNDHHFPSTSEEDAALIYNYNSTFTGKHSNFMQCYYFEQ
176
F6VE62
3.2.1.52
ACT_SITE 336; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MEQRGWGLPRLLGLLALLAVQVPRSSASSYMGLWPLPLSVEMSPRLLRLSPENFHIGHDSSSTAGPSCTILQEAFRRYYDYIFGFYKWHRGPAKSHAAPELEQLLVSVVLDSQCNAFPNVSSDESCEYRVSLLVKGPVAILKANRVWGVLRGLETFSQLIYQDSYGTFTINESNIVDSPRFPHRGILIDTARHYLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPQLSNKGSYSLSHVYTPNDVRIVIEYARLRGIRVIPEFDTPGHAQSWGKGQKDLLTPCYHGHTQSGTFGPINPILNTTYSFLSKFFNEISTVFPDHFIHLGGDEVEFQCWESNPDIQKFMQQKGFGTDFKKLEVFYIQKLFNIISTVNKGSIVWQEVFDNNVKLQPGVVVQVWKYGDYAKEQSRVTAEGFPVLLSAPWYLDYISYGQDWVKYYNVEPLDFDGTSKQKTLVIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSRQDVRSSQDAYKRLTVHRCRMVRRGVAAEPLFTGYCNHEDRV
170
A0A0A0K5W3
1.11.1.7
ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MEIRKCKMQSELSGELAKIVALLMVGLVMISKGHSQELKVGFYSETCPLAETIVRTTVAKAVSQNPGMAAGIIRMHFHDCIVLGCDASILLDKTPENPDTEKGVNVGNPLLRGFEIIDDAKFEIETRCPQTVSCADILAFAARDSVATLGQFTYDVPSGRRDSLVSHGANVSDNIPFPTTDIGFLAQHFEERGLSLRDMVALSGAHSIGRTGCPEFTDRLFSSNGTEITDPSLDPTFAATLRQKCPFGSGFDKTADLDNVTPNHLDIQFFENLKNKMGVLSSDQAIATDPLTAAIVSRYQGNRAIWMRDFSAAMVKMGKLLVLTGTQGEIRKECHFRN
14